Cited 36 times in
Graphene-Iodine Nanocomposites Highly Potent Bacterial Inhibitors that are Bio-compatible with Human Cells
DC Field | Value | Language |
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dc.contributor.author | 김상겸 | - |
dc.date.accessioned | 2017-02-24T03:39:36Z | - |
dc.date.available | 2017-02-24T03:39:36Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146408 | - |
dc.description.abstract | Graphene-composites, capable of inhibiting bacterial growth which is also bio-compatible with human cells have been highly sought after. Here we report for the first time the preparation of new graphene-iodine nano-composites via electrostatic interactions between positively charged graphene derivatives and triiodide anions. The resulting composites were characterized by X-ray photoemission spectroscopy, UV-spectroscopy, Raman spectroscopy and Scanning electron microscopy. The antibacterial potential of these graphene-iodine composites against Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirobilis, Staphylococcus aureus, and E. coli was investigated. In addition, the cytotoxicity of the nanocomposite with human cells [human white blood cells (WBC), HeLa, MDA-MB-231, Fibroblast (primary human keratinocyte) and Keratinocyte (immortalized fibroblast)], was assessed. DGO (Double-oxidizes graphene oxide) was prepared by the additional oxidation of GO (graphene oxide). This generates more oxygen containing functional groups that can readily trap more H(+), thus generating a positively charged surface area under highly acidic conditions. This step allowed bonding with a greater number of anionic triiodides and generated the most potent antibacterial agent among graphene-iodine and as-made povidone-iodine (PVP-I) composites also exhibited nontoxic to human cells culture. Thus, these nano-composites can be used to inhibit the growth of various bacterial species. Importantly, they are also very low-cytotoxic to human cells culture. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biocompatible Materials/chemistry* | - |
dc.subject.MESH | Biocompatible Materials/pharmacology | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Escherichia coli/drug effects | - |
dc.subject.MESH | Graphite/chemistry* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-8/analysis | - |
dc.subject.MESH | Iodine/chemistry* | - |
dc.subject.MESH | Klebsiella pneumoniae/drug effects | - |
dc.subject.MESH | Microscopy, Electron, Scanning | - |
dc.subject.MESH | Nanocomposites/chemistry* | - |
dc.subject.MESH | Oxidation-Reduction | - |
dc.subject.MESH | Photoelectron Spectroscopy | - |
dc.subject.MESH | Pseudomonas aeruginosa/drug effects | - |
dc.subject.MESH | Spectrophotometry, Ultraviolet | - |
dc.subject.MESH | Spectrum Analysis, Raman | - |
dc.subject.MESH | Staphylococcus aureus/drug effects | - |
dc.title | Graphene-Iodine Nanocomposites Highly Potent Bacterial Inhibitors that are Bio-compatible with Human Cells | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Surajit Some | - |
dc.contributor.googleauthor | Ji Soo Sohn | - |
dc.contributor.googleauthor | Junmoo Kim | - |
dc.contributor.googleauthor | Su-Hyun Lee | - |
dc.contributor.googleauthor | Su Chan Lee | - |
dc.contributor.googleauthor | Jungpyo Lee | - |
dc.contributor.googleauthor | Iman Shackery | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | So Hyun Kim | - |
dc.contributor.googleauthor | NakwonChoi | - |
dc.contributor.googleauthor | Il-JooCho | - |
dc.contributor.googleauthor | Hyo-Il Jung | - |
dc.contributor.googleauthor | Shinill Kang | - |
dc.contributor.googleauthor | SeongChan Jun | - |
dc.identifier.doi | 10.1038/srep20015 | - |
dc.contributor.localId | A00520 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 26843066 | - |
dc.contributor.alternativeName | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | Kim, Sang Kyum | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 20015 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.6 : 20015, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47916 | - |
dc.type.rims | ART | - |
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