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Human papillomavirus and epidermal growth factor receptor in oral cavity and oropharyngeal squamous cell carcinoma: Correlation with dynamic contrast-enhanced MRI parameters

Authors
 Yoon Seong Choi  ;  Mina Park  ;  Hyeong Ju Kwon  ;  Yoon Woo Koh  ;  Seung-Koo Lee  ;  Jinna Kim 
Citation
 American Journal of Roentgenology, Vol.206(2) : 408-413, 2016 
Journal Title
 American Journal of Roentgenology 
ISSN
 0361-803X 
Issue Date
2016
MeSH
Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/isolation & purification ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell*/chemistry ; Carcinoma, Squamous Cell*/metabolism ; Carcinoma, Squamous Cell*/pathology ; Carcinoma, Squamous Cell*/virology ; Contrast Media ; Female ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mouth/chemistry ; Mouth/pathology ; Mouth/virology ; Mouth Neoplasms*/chemistry ; Mouth Neoplasms*/metabolism ; Mouth Neoplasms*/pathology ; Mouth Neoplasms*/virology ; Oropharyngeal Neoplasms*/chemistry ; Oropharyngeal Neoplasms*/metabolism ; Oropharyngeal Neoplasms*/pathology ; Oropharyngeal Neoplasms*/virology ; Papillomaviridae/isolation & purification* ; Receptor, Epidermal Growth Factor/metabolism* ; Retrospective Studies
Keywords
MRI ; epidermal growth factor receptor ; head and neck neoplasms ; human papillomavirus ; squamous cell carcinoma
Abstract
OBJECTIVE: The objective of this study was to investigate differences in dynamic contrast-enhanced MRI (DCE-MRI) parameters on the basis of the status of human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) biomarkers in patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by use of histogram analysis. MATERIALS AND METHODS: A total of 22 consecutive patients with oral cavity and oropharyngeal SCC underwent DCE-MRI before receiving treatment. DCE parameter maps of the volume transfer constant (K(trans)), the flux rate constant (kep), and the extravascular extracellular volume fraction (ve) were obtained. The histogram parameters were calculated using the entire enhancing tumor volume and were compared between the patient subgroups on the basis of HPV and EGFR biomarker statuses. RESULTS: The cumulative histogram parameters of K(trans) and kep showed lower values in the HPV-negative and EFGR-overexpression group than in the HPV-positive EGFR-negative group. These differences were statistically significant for the mean (p = 0.009), 25th, 50th, and 75th percentile values of K(trans) and for the 25th percentile value of kep when correlated with HPV status in addition to the mean K(trans) value (p = 0.047) and kep value (p = 0.004) when correlated with EGFR status. No statistically significant difference in ve was found on the basis of HPV and EGFR status. CONCLUSION: DCE-MRI is useful for the assessment of the tumor microenvironment associated with HPV and EGFR biomarkers before treatment of patients with oral cavity and oropharyngeal SCC.
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.15.14713
DOI
10.2214/AJR.15.14713
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
고윤우(Kho, Yoon Woo)
김진아(Kim, Jinna) ORCID logo https://orcid.org/0000-0002-9978-4356
박미나(Park, Mina) ORCID logo https://orcid.org/0000-0002-2005-7560
이승구(Lee, Seung Koo) ORCID logo https://orcid.org/0000-0001-5646-4072
최윤성(Choi, Yoon Seong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146400
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