Cited 63 times in
Absence of Coronary Artery Calcium Identifies Asymptomatic Diabetic Individuals at Low Near-Term But Not Long-Term Risk of Mortality: A 15-Year Follow-Up Study of 9715 Patients
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2017-02-24T03:33:58Z | - |
dc.date.available | 2017-02-24T03:33:58Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1941-9651 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146378 | - |
dc.description.abstract | BACKGROUND: Data regarding coronary artery calcification (CAC) prognosis in diabetic individuals are limited to 5-years follow-up. We investigated the long-term risk stratification of CAC among diabetic compared with nondiabetic individuals. METHODS AND RESULTS: Nine thousand seven hundred and fifteen asymptomatic individuals undergoing CAC scoring were followed for a median (interquartile range) of 14.7 (13.9-15.6) years. The incidence density rate and hazard ratios with 95% confidence intervals were used to calculate all-cause mortality. Incremental prognostic utility of CAC was evaluated using the area under the receiver operator characteristic curve and net reclassification improvement. Diabetics (54.7±10.8 years; 59.4% male) comprised 8.3% of the cohort (n=810), of which 188 (23.2%) died. For CAC=0, the rate of mortality was similar between diabetic and nondiabetic individuals for the first 5 years (P>0.05), with a nonlinear increased risk of mortality for diabetics after 5 years (P<0.05). The adjusted risk of death for those in the highest (CAC>400) versus the lowest (CAC=0) category of CAC increased by a hazards of 4.64 (95% confidence interval =3.74-5.76) and 3.41 (95% confidence interval =2.22-5.22) for nondiabetic and diabetic individuals, respectively. The presence of CAC improved discrimination (area under the receiver operator characteristic curve range: 0.73-0.74; P<0.01) and reclassification (category-free net reclassification improvement range: 0.53-0.50; P<0.001) beyond conventional risk factors in nondiabetic and diabetic individuals, respectively. CONCLUSIONS: CAC=0 is associated with a favorable 5-year prognosis for asymptomatic diabetic and nondiabetic individuals. After 5 years, the risk of mortality increases significantly for diabetic individuals even in the presence of a baseline CAC=0. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | CIRCULATION-CARDIOVASCULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cause of Death | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging* | - |
dc.subject.MESH | Coronary Artery Disease/epidemiology | - |
dc.subject.MESH | Coronary Artery Disease/mortality* | - |
dc.subject.MESH | Diabetes Mellitus/epidemiology | - |
dc.subject.MESH | Diabetes Mellitus/mortality* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Tomography, X-Ray Computed/methods* | - |
dc.subject.MESH | Vascular Calcification/diagnostic imaging* | - |
dc.subject.MESH | Vascular Calcification/epidemiology | - |
dc.subject.MESH | Vascular Calcification/mortality* | - |
dc.title | Absence of Coronary Artery Calcium Identifies Asymptomatic Diabetic Individuals at Low Near-Term But Not Long-Term Risk of Mortality: A 15-Year Follow-Up Study of 9715 Patients | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Valentina Valenti | - |
dc.contributor.googleauthor | Bríain ó Hartaigh | - |
dc.contributor.googleauthor | Iksung Cho | - |
dc.contributor.googleauthor | Joshua Schulman-Marcus | - |
dc.contributor.googleauthor | Heidi Gransar | - |
dc.contributor.googleauthor | Ran Heo | - |
dc.contributor.googleauthor | Quynh A. Truong | - |
dc.contributor.googleauthor | Leslee J. Shaw | - |
dc.contributor.googleauthor | Joseph Knapper | - |
dc.contributor.googleauthor | Anita A. Kelkar | - |
dc.contributor.googleauthor | Sebastiano Sciarretta | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Tracy Q. Callister | - |
dc.contributor.googleauthor | James K. Min | - |
dc.identifier.doi | 10.1161/CIRCIMAGING.115.003528 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A04348 | - |
dc.contributor.localId | A03888 | - |
dc.relation.journalcode | J00538 | - |
dc.identifier.eissn | 1942-0080 | - |
dc.identifier.pmid | 26848062 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=01337498-201602000-00005&LSLINK=80&D=ovft | - |
dc.subject.keyword | calcium score | - |
dc.subject.keyword | computed tomography | - |
dc.subject.keyword | coronary artery calcium | - |
dc.subject.keyword | diabetes mellitus | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 003528 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR IMAGING, Vol.9(2) : 003528, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47886 | - |
dc.type.rims | ART | - |
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