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Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery

DC Field Value Language
dc.contributor.author곽영란-
dc.contributor.author소사라-
dc.contributor.author심재광-
dc.contributor.author조진선-
dc.date.accessioned2017-02-24T03:33:17Z-
dc.date.available2017-02-24T03:33:17Z-
dc.date.issued2016-
dc.identifier.issn0085-2538-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146374-
dc.description.abstractAcute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular heart surgery. Two hundred patients undergoing valvular heart surgery were randomly assigned to equal placebo or treatment groups. Dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continuing for 24 h after surgery. We then assessed the incidence of AKI during the first 48 postoperative hours, hemodynamic variables, and a composite of major morbidity end points. The incidence of AKI, based on Acute Kidney Injury Network criteria, was significantly lower in the treatment group compared with the control group (14 vs. 33%). The dexmedetomidine group exhibited a significantly lower incidence of a composite of major morbidity end points (21 vs. 38%) and a significantly shorter length of intensive care unit stay (3 [2, 3] days vs. 3 [2, 4] days) compared with the control group. Thus, perioperative infusion of dexmedetomidine effectively reduced both the incidence and severity of AKI, and improved outcome in patients undergoing valvular heart surgery without untoward hemodynamic side effects.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent693~700-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfKIDNEY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Kidney Injury/epidemiology-
dc.subject.MESHAcute Kidney Injury/physiopathology-
dc.subject.MESHAcute Kidney Injury/prevention & control*-
dc.subject.MESHAdrenergic alpha-2 Receptor Agonists/administration & dosage*-
dc.subject.MESHAdrenergic alpha-2 Receptor Agonists/adverse effects-
dc.subject.MESHAged-
dc.subject.MESHCardiac Surgical Procedures/adverse effects*-
dc.subject.MESHDexmedetomidine/administration & dosage*-
dc.subject.MESHDexmedetomidine/adverse effects-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHFemale-
dc.subject.MESHHeart Valve Diseases/physiopathology-
dc.subject.MESHHeart Valve Diseases/surgery*-
dc.subject.MESHHeart Valves/physiopathology-
dc.subject.MESHHeart Valves/surgery*-
dc.subject.MESHHemodynamics/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHInfusions, Parenteral-
dc.subject.MESHLength of Stay-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titlePerioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorJin Sun Cho-
dc.contributor.googleauthorJae-Kwang Shim-
dc.contributor.googleauthorSara Soh-
dc.contributor.googleauthorMin Kyung Kim-
dc.contributor.googleauthorYoung-Lan Kwak-
dc.identifier.doi10.1038/ki.2015.306-
dc.contributor.localIdA00172-
dc.contributor.localIdA01960-
dc.contributor.localIdA02205-
dc.contributor.localIdA03914-
dc.relation.journalcodeJ01941-
dc.identifier.eissn1523-1755-
dc.identifier.pmid26444030-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0085253815000344-
dc.subject.keywordacute kidney injury-
dc.subject.keywordcardiac surgery-
dc.subject.keywordcardiopulmonary bypass-
dc.subject.keyworddexmedetomidine-
dc.contributor.alternativeNameKwak, Young Lan-
dc.contributor.alternativeNameSoh, Sa Rah-
dc.contributor.alternativeNameShim, Jae Kwang-
dc.contributor.alternativeNameCho, Jin Sun-
dc.contributor.affiliatedAuthorKwak, Young Lan-
dc.contributor.affiliatedAuthorSoh, Sa Rah-
dc.contributor.affiliatedAuthorShim, Jae Kwang-
dc.contributor.affiliatedAuthorCho, Jin Sun-
dc.citation.volume89-
dc.citation.number3-
dc.citation.startPage693-
dc.citation.endPage700-
dc.identifier.bibliographicCitationKIDNEY INTERNATIONAL, Vol.89(3) : 693-700, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47882-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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