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Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 소사라 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 조진선 | - |
dc.date.accessioned | 2017-02-24T03:33:17Z | - |
dc.date.available | 2017-02-24T03:33:17Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146374 | - |
dc.description.abstract | Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular heart surgery. Two hundred patients undergoing valvular heart surgery were randomly assigned to equal placebo or treatment groups. Dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continuing for 24 h after surgery. We then assessed the incidence of AKI during the first 48 postoperative hours, hemodynamic variables, and a composite of major morbidity end points. The incidence of AKI, based on Acute Kidney Injury Network criteria, was significantly lower in the treatment group compared with the control group (14 vs. 33%). The dexmedetomidine group exhibited a significantly lower incidence of a composite of major morbidity end points (21 vs. 38%) and a significantly shorter length of intensive care unit stay (3 [2, 3] days vs. 3 [2, 4] days) compared with the control group. Thus, perioperative infusion of dexmedetomidine effectively reduced both the incidence and severity of AKI, and improved outcome in patients undergoing valvular heart surgery without untoward hemodynamic side effects. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 693~700 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | KIDNEY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Kidney Injury/epidemiology | - |
dc.subject.MESH | Acute Kidney Injury/physiopathology | - |
dc.subject.MESH | Acute Kidney Injury/prevention & control* | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/administration & dosage* | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/adverse effects | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiac Surgical Procedures/adverse effects* | - |
dc.subject.MESH | Dexmedetomidine/administration & dosage* | - |
dc.subject.MESH | Dexmedetomidine/adverse effects | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Valve Diseases/physiopathology | - |
dc.subject.MESH | Heart Valve Diseases/surgery* | - |
dc.subject.MESH | Heart Valves/physiopathology | - |
dc.subject.MESH | Heart Valves/surgery* | - |
dc.subject.MESH | Hemodynamics/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Infusions, Parenteral | - |
dc.subject.MESH | Length of Stay | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Sara Soh | - |
dc.contributor.googleauthor | Min Kyung Kim | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1038/ki.2015.306 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01960 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A03914 | - |
dc.relation.journalcode | J01941 | - |
dc.identifier.eissn | 1523-1755 | - |
dc.identifier.pmid | 26444030 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0085253815000344 | - |
dc.subject.keyword | acute kidney injury | - |
dc.subject.keyword | cardiac surgery | - |
dc.subject.keyword | cardiopulmonary bypass | - |
dc.subject.keyword | dexmedetomidine | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Soh, Sa Rah | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.alternativeName | Cho, Jin Sun | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Soh, Sa Rah | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Cho, Jin Sun | - |
dc.citation.volume | 89 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 693 | - |
dc.citation.endPage | 700 | - |
dc.identifier.bibliographicCitation | KIDNEY INTERNATIONAL, Vol.89(3) : 693-700, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47882 | - |
dc.type.rims | ART | - |
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