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Use of TachoSil® patches to prevent pancreatic leaks after distal pancreatectomy: a prospective, multicenter, randomized controlled study

DC FieldValueLanguage
dc.contributor.author강창무-
dc.contributor.author박준성-
dc.contributor.author윤동섭-
dc.contributor.author이우정-
dc.contributor.author황호경-
dc.contributor.author김재근-
dc.date.accessioned2017-02-24T03:25:35Z-
dc.date.available2017-02-24T03:25:35Z-
dc.date.issued2016-
dc.identifier.issn1868-6974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146341-
dc.description.abstractBACKGROUND: We performed a prospective, multicenter, randomized controlled study to investigate the clinical outcomes, including postoperative pancreatic fistulas (POPF), after using the TachoSil® patch in distal pancreatectomy (NCT01550406). METHODS: Between June 2012 and September 2014, 101 patients at five centers were randomized into Control (n = 53) and TachoSil (n = 48) groups. In all patients, the pancreas was resected using a stapler with Endo-GIA™ staples. The TachoSil patch was wrapped around the pancreatic stump only in the TachoSil group, not in Control group. RESULTS: The patient characteristics, including age and diagnosis, were comparable in both groups. The mean operation time (159.4 vs. 172.3 min, P = 0.081) and postoperative hospital stay (10.0 vs. 9.7 days, P = 0.279) were similar in the Control and TachoSil groups, respectively. The overall incidence of POPF was 62.4% (n = 63). The distribution of grades A, B, and C POPF was similar in the Control (n = 14/14/1) and TachoSil (n = 23/11/0) groups, as were the overall incidence (54.7% vs. 70.8%, P = 0.095) and the incidence of grade B and C POPF (28.3% vs. 22.9%, P = 0.536). CONCLUSION: This study showed that the TachoSil® patch did not reduce the incidence of POPF after distal pancreatectomy.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent110~117-
dc.languageEnglish-
dc.publisherWiley Japan-
dc.relation.isPartOfJournal of Hepato-Biliary-Pancreatic Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDrug Combinations-
dc.subject.MESHFemale-
dc.subject.MESHFibrinogen/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHLength of Stay-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOperative Time-
dc.subject.MESHPancreas/anatomy & histology-
dc.subject.MESHPancreatectomy*-
dc.subject.MESHPancreatic Fistula/etiology-
dc.subject.MESHPancreatic Fistula/prevention & control-
dc.subject.MESHPostoperative Complications/prevention & control*-
dc.subject.MESHProspective Studies-
dc.subject.MESHThrombin/therapeutic use*-
dc.subject.MESHYoung Adult-
dc.titleUse of TachoSil® patches to prevent pancreatic leaks after distal pancreatectomy: a prospective, multicenter, randomized controlled study-
dc.typeArticle-
dc.publisher.locationJapan-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorDoo-ho Lee-
dc.contributor.googleauthorJin-Young Jang-
dc.contributor.googleauthorYoungmin Han-
dc.contributor.googleauthorDong Sup Yoon-
dc.contributor.googleauthorJae Keun Kim-
dc.contributor.googleauthorHo-Seong Han-
dc.contributor.googleauthorYooSeok Yoon-
dc.contributor.googleauthorDaeWook Hwang-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorJinSeok Heo-
dc.contributor.googleauthorYe Rim Chang-
dc.contributor.googleauthorMee Joo Kang-
dc.contributor.googleauthorYong Chan Shin-
dc.contributor.googleauthorJihoon Chang-
dc.contributor.googleauthorHongbeom Kim-
dc.contributor.googleauthorWoohyun Jung-
dc.contributor.googleauthorSun-Whe Kim-
dc.identifier.doi10.1002/jhbp.310-
dc.contributor.localIdA00088-
dc.contributor.localIdA01672-
dc.contributor.localIdA02548-
dc.contributor.localIdA02993-
dc.contributor.localIdA04497-
dc.contributor.localIdA00857-
dc.relation.journalcodeJ01440-
dc.identifier.pmid26681272-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jhbp.310/abstract-
dc.subject.keywordDistal pancreatectomy-
dc.subject.keywordPostoperative pancreatic fistula-
dc.subject.keywordPrevention-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNamePark, Joon Seong-
dc.contributor.alternativeNameYoon, Dong Sup-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameHwang, Ho Kyoung-
dc.contributor.alternativeNameKim, Jae Keun-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorPark, Joon Seong-
dc.contributor.affiliatedAuthorYoon, Dong Sup-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorHwang, Ho Kyoung-
dc.contributor.affiliatedAuthorKim, Jae Keun-
dc.citation.volume23-
dc.citation.number2-
dc.citation.startPage110-
dc.citation.endPage117-
dc.identifier.bibliographicCitationJournal of Hepato-Biliary-Pancreatic Sciences, Vol.23(2) : 110-117, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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