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Use of TachoSil® patches to prevent pancreatic leaks after distal pancreatectomy: a prospective, multicenter, randomized controlled study

 Joon Seong Park  ;  Doo-ho Lee  ;  Jin-Young Jang  ;  Youngmin Han  ;  Dong Sup Yoon  ;  Jae Keun Kim  ;  Ho-Seong Han  ;  YooSeok Yoon  ;  DaeWook Hwang  ;  Chang Moo Kang  ;  Ho Kyoung Hwang  ;  Woo Jung Lee  ;  JinSeok Heo  ;  Ye Rim Chang  ;  Mee Joo Kang  ;  Yong Chan Shin  ;  Jihoon Chang  ;  Hongbeom Kim  ;  Woohyun Jung  ;  Sun-Whe Kim 
 Journal of Hepato-Biliary-Pancreatic Sciences, Vol.23(2) : 110-117, 2016 
Journal Title
 Journal of Hepato-Biliary-Pancreatic Sciences 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Drug Combinations ; Female ; Fibrinogen/therapeutic use* ; Humans ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Pancreas/anatomy & histology ; Pancreatectomy* ; Pancreatic Fistula/etiology ; Pancreatic Fistula/prevention & control ; Postoperative Complications/prevention & control* ; Prospective Studies ; Thrombin/therapeutic use* ; Young Adult
Distal pancreatectomy ; Postoperative pancreatic fistula ; Prevention
BACKGROUND: We performed a prospective, multicenter, randomized controlled study to investigate the clinical outcomes, including postoperative pancreatic fistulas (POPF), after using the TachoSil® patch in distal pancreatectomy (NCT01550406). METHODS: Between June 2012 and September 2014, 101 patients at five centers were randomized into Control (n = 53) and TachoSil (n = 48) groups. In all patients, the pancreas was resected using a stapler with Endo-GIA™ staples. The TachoSil patch was wrapped around the pancreatic stump only in the TachoSil group, not in Control group. RESULTS: The patient characteristics, including age and diagnosis, were comparable in both groups. The mean operation time (159.4 vs. 172.3 min, P = 0.081) and postoperative hospital stay (10.0 vs. 9.7 days, P = 0.279) were similar in the Control and TachoSil groups, respectively. The overall incidence of POPF was 62.4% (n = 63). The distribution of grades A, B, and C POPF was similar in the Control (n = 14/14/1) and TachoSil (n = 23/11/0) groups, as were the overall incidence (54.7% vs. 70.8%, P = 0.095) and the incidence of grade B and C POPF (28.3% vs. 22.9%, P = 0.536). CONCLUSION: This study showed that the TachoSil® patch did not reduce the incidence of POPF after distal pancreatectomy.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Jae Keun(김재근)
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
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