Cited 15 times in
Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김신형 | - |
dc.contributor.author | 나성원 | - |
dc.contributor.author | 신서경 | - |
dc.contributor.author | 오영준 | - |
dc.contributor.author | 최용선 | - |
dc.date.accessioned | 2017-02-24T03:19:57Z | - |
dc.date.available | 2017-02-24T03:19:57Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146315 | - |
dc.description.abstract | PURPOSE: Oxidative stress during CO₂ pneumoperitoneum is reported to be associated with decreased bioactivity of nitric oxide (NO). However, the changes in endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and arginase during CO₂ pneumoperitoneum have not been elucidated. MATERIALS AND METHODS: Thirty male Sprague-Dawley rats were randomized into three groups. After anesthesia induction, the abdominal cavities of the rats of groups intra-abdominal pressure (IAP)-10 and IAP-20 were insufflated with CO₂ at pressures of 10 mm Hg and 20 mm Hg, respectively, for 2 hours. The rats of group IAP-0 were not insufflated. After deflation, plasma NO was measured, while protein expression levels and activity of eNOS, iNOS, arginase (Arg) I, and Arg II were analyzed with aorta and lung tissue samples. RESULTS: Plasma nitrite concentration and eNOS expression were significantly suppressed in groups IAP-10 and IAP-20 compared to IAP-0. While expression of iNOS and Arg I were comparable between the three groups, Arg II expression was significantly greater in group IAP-20 than in group IAP-0. Activity of eNOS was significantly lower in groups IAP-10 and IAP-20 than in group IAP-0, while iNOS activity was significantly greater in group IAP-20 than in groups IAP-0 and IAP-10. Arginase activity was significantly greater in group IAP-20 than in groups IAP-0 and IAP-10. CONCLUSION: The activity of eNOS decreases during CO₂ pneumoperitoneum, while iNOS activity is significantly increased, a change that contributes to increased oxidative stress and inflammation. Moreover, arginase expression and activity is increased during CO₂ pneumoperitoneum, which seems to act inversely to the NO system. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 238~246 | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aorta/physiology* | - |
dc.subject.MESH | Arginase/antagonists & inhibitors* | - |
dc.subject.MESH | Enzyme Inhibitors/administration & dosage | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Inflammation/etiology | - |
dc.subject.MESH | Inflammation/prevention & control* | - |
dc.subject.MESH | Injections, Subcutaneous | - |
dc.subject.MESH | Lung Injury/etiology | - |
dc.subject.MESH | Lung Injury/prevention & control | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nitric Oxide/metabolism | - |
dc.subject.MESH | Nitric Oxide Synthase Type II/metabolism* | - |
dc.subject.MESH | Nitric Oxide Synthase Type III/metabolism* | - |
dc.subject.MESH | Oxidative Stress/drug effects* | - |
dc.subject.MESH | Pneumoperitoneum/complications* | - |
dc.subject.MESH | Pneumoperitoneum/drug therapy | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Seokyung Shin | - |
dc.contributor.googleauthor | Sungwon Na | - |
dc.contributor.googleauthor | Ok Soo Kim | - |
dc.contributor.googleauthor | Yong Seon Choi | - |
dc.contributor.googleauthor | Shin Hyung Kim | - |
dc.contributor.googleauthor | Young Jun Oh | - |
dc.identifier.doi | 10.3349/ymj.2016.57.1.238 | - |
dc.contributor.localId | A00676 | - |
dc.contributor.localId | A01232 | - |
dc.contributor.localId | A02109 | - |
dc.contributor.localId | A02389 | - |
dc.contributor.localId | A04119 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 26632407 | - |
dc.subject.keyword | Arginase | - |
dc.subject.keyword | nitric oxide synthase | - |
dc.subject.keyword | oxidative stress | - |
dc.subject.keyword | pneumoperitoneum | - |
dc.contributor.alternativeName | Kim, Shin Hyung | - |
dc.contributor.alternativeName | Na, Sung Won | - |
dc.contributor.alternativeName | Shin, Seo Kyung | - |
dc.contributor.alternativeName | Oh, Young Jun | - |
dc.contributor.alternativeName | Choi, Yong Seon | - |
dc.contributor.affiliatedAuthor | Kim, Shin Hyung | - |
dc.contributor.affiliatedAuthor | Na, Sung Won | - |
dc.contributor.affiliatedAuthor | Shin, Seo Kyung | - |
dc.contributor.affiliatedAuthor | Oh, Young Jun | - |
dc.contributor.affiliatedAuthor | Choi, Yong Seon | - |
dc.citation.volume | 57 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 238 | - |
dc.citation.endPage | 246 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(1) : 238-246, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 53080 | - |
dc.type.rims | ART | - |
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