Cited 12 times in
Distinct subgroups of paroxysmal nocturnal hemoglobinuria (PNH) with cytopenia: results from South Korean National PNH Registry
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2017-02-24T03:14:22Z | - |
dc.date.available | 2017-02-24T03:14:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146286 | - |
dc.description.abstract | We retrospectively assessed the clinical characteristics of patients with paroxysmal nocturnal hemoglobinuria (PNH) according to severity of cytopenia. A total of 282 patients with hematological parameters assessed at the time of diagnosis of PNH were included. There were 24 patients with PNH/severe aplastic anemia (SAA) (at least two of the three criteria; hemoglobin ≤8 g/dL; absolute neutrophil count (ANC) <0.5 × 10(9)/L; platelet count <20 × 10(9)/L), 96 patients with PNH/aplastic anemia (AA) (at least two of the three criteria; hemoglobin ≤10 g/dL; ANC 0.5-1.5 × 10(9)/L; platelet count 20-100 × 10(9)/L), and 162 classic PNH patients. Compared with the classic PNH subgroup, the PNH/SAA subgroup had a significantly lower median granulocyte PNH clone size (26.7 vs. 51.0 %, P = 0.021) and lower incidence of lactate dehydrogenase ≥1.5 times the upper limit of normal (52.9 vs. 80.0 %, P = 0.049). The incidence of thromboembolism was similar in both subgroups. Overall survival was significantly lower in the PNH/SAA subgroup than in the classic PNH subgroup (P = 0.033). Our findings suggest that identification of patients with PNH/SAA at the time of diagnosis is important because of different clinical manifestations and poorer outcome compared with patients with classic PNH (clinicaltrials.gov identifier: #NCT01224483). | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 125~133 | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal/classification* | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal/diagnosis* | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal/mortality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pancytopenia/classification* | - |
dc.subject.MESH | Pancytopenia/diagnosis* | - |
dc.subject.MESH | Pancytopenia/mortality | - |
dc.subject.MESH | Registries* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.subject.MESH | Young Adult | - |
dc.title | Distinct subgroups of paroxysmal nocturnal hemoglobinuria (PNH) with cytopenia: results from South Korean National PNH Registry | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Jun Ho Jang | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.contributor.googleauthor | Je-Hwan Lee | - |
dc.contributor.googleauthor | Yeo-Kyeoung Kim | - |
dc.contributor.googleauthor | Deog-Yeon Jo | - |
dc.contributor.googleauthor | Joo Seop Chung | - |
dc.contributor.googleauthor | Sang Kyun Sohn | - |
dc.contributor.googleauthor | Jong Wook Lee | - |
dc.identifier.doi | 10.1007/s00277-015-2511-z | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J00161 | - |
dc.identifier.eissn | 1432-0584 | - |
dc.identifier.pmid | 26416513 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s00277-015-2511-z | - |
dc.subject.keyword | Aplastic anemia | - |
dc.subject.keyword | Cytopenia | - |
dc.subject.keyword | Paroxysmal nocturnal hemoglobinuria | - |
dc.subject.keyword | Thromboembolism | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.citation.volume | 95 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 125 | - |
dc.citation.endPage | 133 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, Vol.95(1) : 125-133, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 51371 | - |
dc.type.rims | ART | - |
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