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Definitive Chemoradiotherapy Versus Surgery Followed by Adjuvant Radiotherapy in Resectable Stage III/IV Hypopharyngeal Cancer

DC FieldValueLanguage
dc.contributor.author금기창-
dc.contributor.author김세헌-
dc.contributor.author김주항-
dc.contributor.author김준원-
dc.contributor.author이창걸-
dc.date.accessioned2017-02-24T03:12:46Z-
dc.date.available2017-02-24T03:12:46Z-
dc.date.issued2016-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146278-
dc.description.abstractPURPOSE: The purpose of this study is to compare the treatment outcomes for locally advanced resectable hypopharyngeal cancer between organ-preserving chemoradiotherapy (CRT) and surgery followed by radiotherapy (SRT). MATERIALS AND METHODS: We reviewed 91 patients with stage III/IV hypopharyngeal squamous cell carcinoma treated with radiotherapy (RT). In the CRT group (n=34), 18 patients were treated with concurrent CRT and 16 patients with induction chemotherapy plus concurrent CRT. In the SRT group (n=57), six patients were treated with total laryngopharyngectomy, 34 patients with total laryngectomy (TL) and partial pharyngectomy (PP), and 17 patients with PP, which were followed by adjuvant radiotherapy (n=41) or CRT (n=16). The median RT dose was 70 Gy for CRT and 59.4 Gy for SRT. RESULTS: Five-year local control (84.1% vs. 90.9%), and disease-free survival (DFS, 51.0% vs. 52.7%) and overall survival (OS, 58.6% vs. 56.6%) showed no significant difference between the CRT and SRT groups. The functional larynx-preservation rate was higher in the CRT group (88.2% vs. 29.8%). Treatment-related toxicity, requiring surgical intervention, occurred more frequently in the SRT group (37% vs. 12%). In the SRT group, TL resulted in a significantly higher DFS than larynx-sparing surgery (63.9% vs. 26.5%, p=0.027). Treatment outcome of the SRT group improved when only patients with TL were considered (n=40); however, 5-year OS (67.1% vs. 58.6%, p=0.830) and DFS (63.9% vs. 51.0%, p=0.490) did not improve significantly when compared to the CRT group. CONCLUSION: Organ preserving CRT provided a treatment outcome that is comparable to SRT for locally advanced hypopharyngeal cancer, while offering an opportunity for functional larynx-preservation and reduced treatment-related toxicity.-
dc.description.statementOfResponsibilityopen-
dc.format.extent45~53-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCancer Research and Treatment-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHChemoradiotherapy*/adverse effects-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypopharyngeal Neoplasms/pathology-
dc.subject.MESHHypopharyngeal Neoplasms/surgery*-
dc.subject.MESHHypopharyngeal Neoplasms/therapy*-
dc.subject.MESHLaryngectomy-
dc.subject.MESHLarynx/physiology-
dc.subject.MESHLarynx/surgery-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPharyngectomy/adverse effects-
dc.subject.MESHRadiotherapy, Adjuvant*/adverse effects-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleDefinitive Chemoradiotherapy Versus Surgery Followed by Adjuvant Radiotherapy in Resectable Stage III/IV Hypopharyngeal Cancer-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorMi Sun Kim-
dc.contributor.googleauthorSe-Heon Kim-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorGwi Eon Kim-
dc.contributor.googleauthorKi Chang Keum-
dc.identifier.doi10.4143/crt.2014.340-
dc.contributor.localIdA00272-
dc.contributor.localIdA00605-
dc.contributor.localIdA00945-
dc.contributor.localIdA00958-
dc.contributor.localIdA03240-
dc.relation.journalcodeJ00453-
dc.relation.journalsince2001~-
dc.identifier.pmid25779363-
dc.relation.journalbefore~2001 Journal of the Korean Cancer Research Association (대한암학회지)-
dc.subject.keywordAdjuvant radiotherapy-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordHypopharyngeal neoplasms-
dc.subject.keywordOrgan preservation-
dc.subject.keywordTreatment outcome-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKim, Se Heon-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Jun Won-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKim, Se Heon-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorKim, Jun Won-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.citation.volume48-
dc.citation.number1-
dc.citation.startPage45-
dc.citation.endPage53-
dc.identifier.bibliographicCitationCancer Research and Treatment, Vol.48(1) : 45-53, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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