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Retinal vessel structure measurement using spectral-domain optical coherence tomography

 TH Rim  ;  YS Choi  ;  SS Kim  ;  M-j Kang  ;  J Oh  ;  S Park  ;  SH Byeon 
 EYE, Vol.30(1) : 111-119, 2016 
Journal Title
Issue Date
Adult ; Anatomy, Cross-Sectional* ; Diagnostic Techniques, Ophthalmological* ; Humans ; Observer Variation ; Optic Disk/blood supply ; Reproducibility of Results ; Retinal Vessels/anatomy & histology* ; Retrospective Studies ; Tomography, Optical Coherence/methods*
PURPOSE: To assess the reliability and validity of spectral-domain optical coherence tomography (SD-OCT) measurements of retinal vessel lumen diameters and wall thicknesses.
METHODS: SD-OCT was used to characterize the circular region around the optic disc of 40 eyes (20 subjects). The inner and outer sides (vitreal and choroidal sides) of the vessel wall and the luminal diameter were measured using intensity graphs.
RESULTS: Mean arterial and venous luminal diameters were 95.1±16.1 and 132.6±17.8 μm, respectively. The wall thicknesses of inner and outer sides of the artery were 23.9±4.9 and 21.2±3.5 μm, respectively. The wall thicknesses of the inner and outer sides of the vein were 20.7±4.2 and 16.3±4.3 μm, respectively. There were significant differences between the inner and outer wall thicknesses in both the artery and vein (P<0.01). Intra- and interobserver intraclass correlation coefficients (ICCs) for lumen measurements were >0.95, and for wall thicknesses were >0.85, except for the outer wall thickness measurements. The mean value of outer and inner wall thicknesses showed good reproducibility, with ICCs of >0.85.
CONCLUSION: Intensity graph-assisted measurements using SD-OCT provided more objective information in finding boundaries of vessels. Luminal diameters and wall thicknesses obtained with OCT showed good overall reproducibility, with inner wall thicknesses being thicker, and with better reproducibility compared with outer wall thicknesses, where ICC values were the lowest among the inner wall thicknesses, mean thicknesses of inner and outer walls, and luminal diameters. When using SD-OCT measurements, caution is therefore advised when using only the outer wall as representative of the wall thicknesses.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, M-j(강민재)
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Oh, Jae Won(오재원) ORCID logo https://orcid.org/0000-0002-4585-1488
Rim, Tyler Hyungtaek(임형택)
Choi, Yoon Seong(최윤성)
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