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Comparison of Six Automated Treponema-Specific Antibody Assays

Authors
 Borae G. Park  ;  Jihoon G. Yoon  ;  John Hoon Rim  ;  Anna Lee  ;  Hyon-Suk Kim 
Citation
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.54(1) : 163-167, 2016 
Journal Title
 JOURNAL OF CLINICAL MICROBIOLOGY 
ISSN
 0095-1137 
Issue Date
2016
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Bacterial/analysis* ; Automation, Laboratory/methods* ; Child ; Child, Preschool ; Clinical Laboratory Techniques/methods* ; Diagnostic Tests, Routine/methods* ; Female ; Humans ; Immunoassay/methods* ; Male ; Mass Screening/methods ; Middle Aged ; Sensitivity and Specificity ; Syphilis/diagnosis* ; Treponema/immunology* ; Young Adult
Abstract
Six different Treponema (TP)-specific immunoassays were compared to the fluorescent treponemal antibody absorption (FTA-ABS) test. A total of 615 samples were tested. The overall percent agreement, analytical sensitivity, and analytical specificity of each assay compared to the FTA-ABS test were as follows: Architect Syphilis TP, 99.2%, 96.8%, and 100%; Cobas Syphilis, 99.8%, 99.4%, and 100%; ADVIA Centaur Syphilis, 99.8%, 99.4%, and 100%; HISCL Anti-TP assay kit, 99.7%, 98.7%, and 100%; Immunoticles Auto3 TP, 99.0%, 97.5%, and 99.6%; Mediace TPLA, 98.0%, 98.1%, and 98.0%. All results that were discrepant between the TP-specific assays were associated with samples from noninfectious cases (11 immunoassay false positives and 7 from previous syphilis cases). Our study demonstrated that TP-specific immunoassays generally showed high sensitivities, specificities, and percentages of agreement compared to FTA-ABS, with rare cases of false-positive or false-negative results. Therefore, most TP-specific immunoassays are acceptable for use in screening for syphilis. However, it is important to perform a thorough review of a patient's clinical and treatment history for interpreting the results of syphilis serology.
Files in This Item:
T201600077.pdf Download
DOI
10.1128/JCM.02593-15
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
Park, Borae G(박금보래)
Yoon, Jihoon G.(윤지훈) ORCID logo https://orcid.org/0000-0002-4401-7803
Rim, John Hoon(임정훈) ORCID logo https://orcid.org/0000-0001-6825-8479
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146247
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