Cited 9 times in
Bactericidal effect through non-uptake pathway with photofunctional silicon polymer that generates reactive oxygen species
DC Field | Value | Language |
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dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2017-01-19T12:56:22Z | - |
dc.date.available | 2017-01-19T12:56:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1010-6030 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/145503 | - |
dc.description.abstract | We report bactericidal effect of photosensitizer (H2TPP: 5,10,15,20-tetraphenyl-21H,23H-porphyrin) through non-uptake pathway and efficacy of the photofunctional silicon polymer to the decomposition of the formed biofilm and the suppression of the biofilm formation. The photofunctional silicon polymer (PSP), which is the silicon polymer embedded with a photosensitizer, is fabricated by a simple solvent swell-encapsulation-shrink method. Reactive oxygen generation from PSP was confirmed by using the decomposition reaction of 1,3-diphnyl-isobenzofuran (DPBF). Also, singlet oxygen generation which is one of the reactive oxygen species (ROS) from PSP is directly confirmed with time and wavelength resolved singlet oxygen phosphorescence spectroscopy. For the influence study of ROS under the non-uptake condition of photosensitizer (PS to bacteria), photodynamic inactivation (PDI) effect of PSP is evaluated for Gram-positive, Gram-negative bacteria, and fungi. Those microorganisms were inactivated by PSP within 1 h under the given power of laser light (63.7 mW/cm2). Among the bacteria, especially, Staphylococcus aureus as the Gram-positive bacteria were completely disinfected under the given experimental condition. Furthermore, PSP successfully demonstrates the decomposition of the formed biofilm and the suppression of the biofilm formation with green light emitting diode (GLED, 3.5 mW/cm2, λmax = 517 nm, FWHM = 37 nm), which shows the practical application possibility of bactericidal material. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 52~58 | - |
dc.language | English | - |
dc.publisher | Elsevier Sequoia | - |
dc.relation.isPartOf | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | - |
dc.title | Bactericidal effect through non-uptake pathway with photofunctional silicon polymer that generates reactive oxygen species | - |
dc.type | Article | - |
dc.publisher.location | Switzerland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Kang-Kyun Wang | - |
dc.contributor.googleauthor | Seung-Jin Jung | - |
dc.contributor.googleauthor | Jeong-Wook Hwang | - |
dc.contributor.googleauthor | Bong-Jin Kim | - |
dc.contributor.googleauthor | Da-Hee Kim | - |
dc.contributor.googleauthor | Il-Kwon Bae | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Yong-Rok Kim | - |
dc.identifier.doi | 10.1016/j.jphotochem.2015.09.005 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J02881 | - |
dc.subject.keyword | Reactive oxygen species | - |
dc.subject.keyword | Bactericidal effect | - |
dc.subject.keyword | Photofunctional polymer | - |
dc.subject.keyword | Non-uptake | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.citation.volume | 315 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 58 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, Vol.315 : 52-58, 2016 | - |
dc.date.modified | 2017-01-16 | - |
dc.identifier.rimsid | 47359 | - |
dc.type.rims | ART | - |
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