Cited 64 times in
The basis for TCR-mediated regulation of the IL-2 receptor α chain gene: Role of widely separated regulatory elements
DC Field | Value | Language |
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dc.contributor.author | 김형표 | - |
dc.date.accessioned | 2016-05-16T11:31:18Z | - |
dc.date.available | 2016-05-16T11:31:18Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144735 | - |
dc.description.abstract | The interleukin-2 receptor α (IL-2Rα) chain is a component of high-affinity IL-2 receptors and thus is a key regulator of lymphocyte proliferation. Lineage-restricted and activation-dependent IL-2Rα transcription is controlled by four upstream positive regulatory regions (PRRs) and one downstream PRR. We now demonstrate that T-cell receptor (TCR) responsiveness requires both upstream sequences and an intronic region, PRRIV, previously identified as an IL-2 response element. Whereas IL-2 responsiveness requires Stat5 and HMG-I(Y) binding, TCR responsiveness of PRRIV requires two AP-1- and two NFAT-binding sites that bind Jun, Fos and NFAT family members in vitro and in vivo. Moreover, IL-2Rα induction is impaired in T lymphocytes from transgenic mice expressing a dominant-negative c-jun construct, or following treatment with cyclosporin A. Thus, our data indicate an important role for both AP-1 and NFAT proteins for TCR-induced IL-2Rα expression and establish that both upstream and intronic sequences mediate TCR responsiveness of the IL-2Rα gene. Moreover, our data reveal a previously unappreciated link between the TCR-mediated up-regulation of the IL-2 and IL-2Rα genes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3051~3059 | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The basis for TCR-mediated regulation of the IL-2 receptor α chain gene: Role of widely separated regulatory elements | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Hyoung-Pyo Kim | - |
dc.contributor.googleauthor | Warren J. Leonard | - |
dc.identifier.doi | 10.1093/emboj/cdf321 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01163 | - |
dc.relation.journalcode | J00763 | - |
dc.identifier.eissn | 1460-2075 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1093/emboj/cdf321/abstract | - |
dc.subject.keyword | AP‐1 | - |
dc.subject.keyword | cyclosporin A | - |
dc.subject.keyword | IL‐2Rα | - |
dc.subject.keyword | NFAT | - |
dc.subject.keyword | TCR | - |
dc.contributor.alternativeName | Kim, Hyoung Pyo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Pyo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3051 | - |
dc.citation.endPage | 3059 | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, Vol.21(12) : 3051-3059, 2002 | - |
dc.identifier.rimsid | 51867 | - |
dc.type.rims | ART | - |
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