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성장 인자가 배양된 토끼의 심부 굴곡 건 세포에서 제1형 교원질 합성에 미치는 영향

DC Field Value Language
dc.contributor.author강응식-
dc.contributor.author강호정-
dc.contributor.author김성재-
dc.contributor.author김현우-
dc.contributor.author한수봉-
dc.contributor.author한창동-
dc.date.accessioned2016-05-16T11:31:09Z-
dc.date.available2016-05-16T11:31:09Z-
dc.date.issued2002-
dc.identifier.issn1226-2102-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144729-
dc.description.abstractPurpose: This study focuses on the change of the expression of type-Ⅰcollagen mRNA and extent of collagen synthesis caused by four kinds of growth factors (TGF-β, IGF-Ⅰ, EGF, PDGF) and their combinations to elucidate the effects of growth factors on rabbit's flexor tendon. Materials and Methods: Cells were isolated from rabbit's flexor tendons and cultured with DMEM containing 0.5% fetal bovine serum. Growth factors were then given either independently or in combination. On the 5th, 10th, and 15th day, the cells were collected and the cell proliferation rate was analyzed. The expression of type-Ⅰ collagen mRNA was analyzed by Northern blot. Results: The expression of type-Ⅰ collagen mRNA increased significantly in the IGF, PDGF, PDGF/EGF, and PDGF/IGF groups (p<0.05). Western blot analysis showed that the extent of type-Ⅰ collagen synthesis in culture media was similar to the type-Ⅰ collagen mRNA expression. Conclusion: Based on this study, we conclude that PDGF and IGF individually, and the combinations PDGF/IGF, and PDGF/EGF were most effective at aiding the healing process in rabbit's flexor tendon.-
dc.description.statementOfResponsibilityopen-
dc.format.extent288~294-
dc.relation.isPartOfJournal of the Korean Orthopaedic Association (대한정형외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title성장 인자가 배양된 토끼의 심부 굴곡 건 세포에서 제1형 교원질 합성에 미치는 영향-
dc.title.alternativeEffect of Growth Factors on Type I Collagen Synthesis in Cultured Rabbit's Deep Flexor Tendon Cell-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthor신동은-
dc.contributor.googleauthor강호정-
dc.contributor.googleauthor김현우-
dc.contributor.googleauthor강응식-
dc.contributor.googleauthor한수봉-
dc.contributor.googleauthor김성재-
dc.contributor.googleauthor한창동-
dc.contributor.googleauthor이우석-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01124-
dc.contributor.localIdA00072-
dc.contributor.localIdA00098-
dc.contributor.localIdA00583-
dc.contributor.localIdA04293-
dc.contributor.localIdA04330-
dc.relation.journalcodeJ01839-
dc.subject.keyword건 세포 배양-
dc.subject.keyword성장 인자-
dc.subject.keyword제 1형 교원질-
dc.subject.keyword토끼 굴곡 건-
dc.subject.keywordTendon cell culture-
dc.subject.keywordGrowth factor-
dc.subject.keywordType-I collagen-
dc.subject.keywordRabbit flexor tendon-
dc.contributor.alternativeNameKang, Eung Shick-
dc.contributor.alternativeNameKang, Ho Jung-
dc.contributor.alternativeNameKim, Sung Jae-
dc.contributor.alternativeNameKim, Hyun Woo-
dc.contributor.alternativeNameHahn, Soo Bong-
dc.contributor.alternativeNameHan, Chang Dong-
dc.contributor.affiliatedAuthorKim, Hyun Woo-
dc.contributor.affiliatedAuthorKang, Eung Shick-
dc.contributor.affiliatedAuthorKang, Ho Jung-
dc.contributor.affiliatedAuthorKim, Sung Jae-
dc.contributor.affiliatedAuthorHahn, Soo Bong-
dc.contributor.affiliatedAuthorHan, Chang Dong-
dc.rights.accessRightsfree-
dc.citation.volume37-
dc.citation.number2-
dc.citation.startPage288-
dc.citation.endPage294-
dc.identifier.bibliographicCitationJournal of the Korean Orthopaedic Association (대한정형외과학회지), Vol.37(2) : 288-294, 2002-
dc.identifier.rimsid51863-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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