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An infection-preventing bilayered collagen membrane containing antibiotic-loaded hyaluronan microparticles: physical and biological properties

 Jong-Eun Lee  ;  Jong-Chul Park  ;  Kwang Hoon Lee  ;  Sang Ho Oh  ;  Joong-Gon Kim  ;  Hwal Suh 
 Artificial Organs, Vol.26(7) : 636-646, 2002 
Journal Title
 Artificial Organs 
Issue Date
Analysis of Variance ; Animals ; Bacterial Infections/prevention & control* ; Biodegradation, Environmental ; Calcium Chloride ; Collagen* ; Drug Carriers* ; Guinea Pigs ; Hyaluronic Acid/administration & dosage* ; Microscopy, Electron, Scanning ; Occlusive Dressings* ; Particle Size ; Pseudomonas aeruginosa/drug effects ; Silver Sulfadiazine/administration & dosage*
Antibacterial capacity ; Bilayered collagen membrane ; Cytotoxicity ; Hyaluronan microparticles ; Regeneration ; Silver sulfadiazine
An infection-preventing bilayered membrane consisting of a dense and porous collagen membrane has been developed. The membrane was fabricated using a combined freeze-drying/air-drying method. Hyaluronan (HA) microparticles containing silver sulfadiazine (AgSD) were fabricated by gelling an HA solution with calcium chloride and were incorporated into collagen layers to allow the sustained release of AgSD. In vitro biodegradability of the membrane and the release of AgSD from the membrane could be controlled by cross-linking the membrane with ultraviolet (UV) irradiation. In a cytotoxicity test, cellular damage was minimized by the sustained release of AgSD from dressings. The antibacterial capacity of the material against Pseudomonas aeruginosa was investigated using the Bauer-Kirby disk diffusion test, and bacterial growth was found to be inhibited for 4 days. In vivo tests showed that the bilayered membrane was associated with greater tissue regeneration than a polymeric membrane and with no infection-related biological signs.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Kwang Hoon(이광훈)
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
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