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비비만인에서 발견되는 비알콜성 지방간의 대사적 의미
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2016-05-16T11:27:53Z | - |
dc.date.available | 2016-05-16T11:27:53Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1738-9364 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144608 | - |
dc.description.abstract | Background : It is well known that non-alcoholic fatty liver disease is associated with metabolic syndrome such as obesity, type II diabetes mellitus, dyslipidemia. Non-alcoholic fatty liver disease is frequently found in non-obese adults, but the meaning of it is unknown. So we studied the association of non-alcoholic fatty liver disease in non-obese adults and metabolic abnormalities. Methods : We examined 779 Korean adults above 30 years old (274 men, 505 women) participating in medical check-up in Health Promotion Center. Hepatitis B and C serologies were negative, and average weekly alcohol intake was .2 drinks. A standard interview, physical examination and biochemical study was conducted. An experienced operator carried out ultrasound liver studies. Results : 370 subjects had non-alcoholic fatty liver disease (47.3%). The frequency in men was higher than that in women (57.3 vs 42.2%, p<0.05). The frequency in non-obese (BMI<25 kg/m2, n=431) group was lower than that in obese (BMI.25 kg/m2, n=348) group (65.5 vs 32.3%, p<0.05). Compared with obese group, waist circumference, waist hip ratio, body fat, impaired fasting serum glucose, total cholesterol, HDL-cholesterol, total cholesterol to HDL-cholesterol ratio, fasting insulin, proinsulin, HOMA-IR and HOMA-beta were significantly different in non-obese, non-alcoholic fatty liver group. After multiple regression analysis, waist circumference was associated with non-alcoholic fatty liver disease in non-obese individuals. Odd ratios of insulin resistance in non-obese, non-alcoholic fatty liver group were 5.8 (CI: 3.1.10.9). Conclusion : The frequency of non-alcoholic fatty liver disease was very high in non-obese adults and well associated with central obesity and insulin resistance | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 488~495 | - |
dc.relation.isPartOf | Korean Journal of Medicine (대한내과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 비비만인에서 발견되는 비알콜성 지방간의 대사적 의미 | - |
dc.title.alternative | Metabolic significance of non-alcoholic fatty liver disease in non-obese adults | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 이광은 | - |
dc.contributor.googleauthor | 김유미 | - |
dc.contributor.googleauthor | 강은석 | - |
dc.contributor.googleauthor | 김혜진 | - |
dc.contributor.googleauthor | 정혜원 | - |
dc.contributor.googleauthor | 이시훈 | - |
dc.contributor.googleauthor | 김형진 | - |
dc.contributor.googleauthor | 김대중 | - |
dc.contributor.googleauthor | 김수경 | - |
dc.contributor.googleauthor | 안철우 | - |
dc.contributor.googleauthor | 차봉수 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.googleauthor | 이현철 | - |
dc.contributor.googleauthor | 허갑범 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J02060 | - |
dc.subject.keyword | Non-alcoholic fatty liver disease | - |
dc.subject.keyword | Body mass index | - |
dc.subject.keyword | Metabolic syndrome | - |
dc.subject.keyword | Central obesity | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 63 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 488 | - |
dc.citation.endPage | 495 | - |
dc.identifier.bibliographicCitation | Korean Journal of Medicine (대한내과학회지), Vol.63(5) : 488-495, 2002 | - |
dc.identifier.rimsid | 51293 | - |
dc.type.rims | ART | - |
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