터너 증후군 환자에서 총 경동맥의 혈관 내막 두께 측정을 통한 잠재성 동맥경화의 관계분석

Abstract

Objective : This study was undertaken to determine whether women with Turner syndrome have greater subclinical atherosclerosis and evaluate the relationship to risk factors for atherosclerosis. Methods : 18 Women with Turner syndrome and 18 women as control group were measured the intima media thickness (IMT) of common carotid artery by B-mode ultrasound. We compared the IMT between cases and controls, and analyzed risk factors which affect the IMT. Results : There are no differences between the groups in age and body mass index (BMI). The height was shorter (147.8±7.9 vs 160.3±5.9, p<0.001) and the waist-hip ratio (WHR) was significantly increased in Turner syndrome (0.86±0.04 vs 0.78±0.04, p<0.001). Fasting blood sugar (FBS) (90.1±9.9 vs 79.4±4.4 ㎎/㎗, p<0.001), fasting insulin (9.5±3.0 vs 4.7±1.0 μIU/㎖, p=0.009), total cholesterol (187.1±21.3 vs 154.8 ±21.8 ㎎/㎗, p=0.014), and LDL (111.3±10.0 vs 82.8±16.4 ㎎/㎗, p=0.009) were significantly higher in Turner syndrome. Compare to control, the IMT was significantly increased in Turner syndrome (0.61±0.09 vs 0.49±0.02 ㎜, p=0.002). In the analysis of correlation between the IMT and clinical & biochemical characteristics, Turner syndrome status, WHR, FBS and fasting insulin were significantly affecting factors (Coefficients of correlation: 0.720, p<0.001; 0.671, P<0.001; 0.445, p=0.020; 0.904, p<0.001). Conclusion : These results suggested that women with Turner syndrome might have an increased risk of subclinical atherosclerosis and insulin resistance was most important risk factor.