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간질에서의 Homocyteine의 중요성

Other Titles
 The significance of homocysteine in epileptic patients 
Authors
 김옥준  ;  김남근  ;  김현조  ;  서정호  ;  이규용  ;  안정용  ;  오도연  ;  김세현 
Citation
 Journal of Korean Epilepsy Society (대한간질학회지), Vol.6(1) : 20-26, 2002 
Journal Title
Journal of Korean Epilepsy Society(대한간질학회지)
ISSN
 1226-6965 
Issue Date
2002
Keywords
Homocystein ; Drug ; MTHFR gene ; Neurological deficits
Abstract
Purpose: Hyperhomocysteinemia was observed in epileptic patients receiving anticonvulsants, especially homozygotes for mtehylenetetrahydrofolate reductase (MTHFR) gene 677C->T mutation. Hyperhomocysteinemia induce atherosclerosis, fetal anticonvulsant syndrome, etc. Therefore, we examined any other factors that might affect the level of homocysteine in epileptic patients.

Methods: We investigated the plasma total homocysteine level in 145 patients with epilepsy. And then we analyzed various factors (clinical findings, neuro-image finding, drugs, MTHFR gene, serum folate and vitamin B12 level) affecting the level of homocysteine.

Results: Among the various factors, male, present neurological deficits, frequent seizure attacks, MTHFR gene 677 TT genotype, polypharmacy, and conventional drug (phenytoin, carbamazepine, valproic acid, phenobarbital, primidone, benzodiazpines) than new drug (lamotrigine, vigabatrin, topiramate, oxcarbazepine zonisamide) were related with elevated homocysteine levels.

Conclusion: We recommend monotherapy with new drugs and higher vitamin requirement in the male epileptic patients of MTHFR TT genotype with neurological deficits and frequent seizure attacks.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Jung Yong(안정용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144525
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