난치성 간질을 동반한 결절성 경화증의 수술적 치험 3례

Abstract

Tuberous sclerosis(TS) is a disorder of aberrant neuronal differentiation and prolifera-tion manifesting as multiple central nervous system(CNS) hamartomas. Seizures in pa-tients with TS are often intractable to anticonvulsant therapy. Although TS shows vari-ous lesions including multiple tubers, many patients with well localized epileptic focus to some tubers may have a benefit from epileptic surgery. We experienced three cases who had clinical improvement after epileptic surgery in intractable epilepsy complicated by TS. We report three cases and the brief review of literatures.