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Altered Expression of Lewis Antigen on Tissue and Erythrocytes in Gastric Cancer Patients

DC Field Value Language
dc.contributor.author김한수-
dc.contributor.author김현옥-
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.date.accessioned2016-05-16T11:19:29Z-
dc.date.available2016-05-16T11:19:29Z-
dc.date.issued2002-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144298-
dc.description.abstractTo elucidate the clinical significance of phenotypic alterations of Lewis antigen in gastric cancer patients, we investigated Lewis antigens by analyzing the genotypes of the Le and Se genes and by comparing the results obtained with the phenotypic expression of Lewis antigen in gastric cancer tissue and blood cells. One hundred and twenty gastric cancer patients were examined and compared with respect to Lewis blood phenotype and genotype. The expression of Lea, Leb, sialylated Lea, and sialylated Lex antigens was immunohistochemically examined in uninvolved gastric mucosa, intestinal metaplasia, and cancerous tissue. We also analyzed the significance of Lewis antigen expression by analyzing patient survival. The frequencies of the Lewis phenotypes of RBCs corresponding to Le(a+b-), Le(a-b+), and Le(a-b-) were 16%, 58%, and 26%, respectively. The Le and le allele gene frequencies calculated from genotyping in gastric cancer patients were 0.623 and 0.377, respectively. The frequency for Le(a-b-) of the RBC phenotype had a tendency to be higher in cancer patients than in normal healthy Koreans. However, no difference in the Lewis gene frequency was found between these gastric cancer patients and healthy persons. The phenotype of Le(a-b+) was most prevalent in uninvolved gastric mucosal tissue, whereas the most prevalent form in tumor tissue was Le(a-b-). Sialyl-Lea and sialyl-Lex antigens were hardly detectable in uninvolved gastric mucosa, whereas the two antigens were expressed highly in intestinal metaplastic mucosa and tumor cells. In conclusion, the loss of Lewis antigen expression in tissue and on RBCs in gastric cancer patients is not a result of genetic influences, but rather a result of sialylation in tissue. We also confirm that poor prognosis is associated with dimeric sialyl-Lex and vascular spread.-
dc.description.statementOfResponsibilityopen-
dc.format.extent427~434-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAlleles-
dc.subject.MESHErythrocytes/chemistry*-
dc.subject.MESHFemale-
dc.subject.MESHFucosyltransferases/analysis*-
dc.subject.MESHFucosyltransferases/genetics-
dc.subject.MESHGangliosides/analysis-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMetaplasia-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOligosaccharides/analysis-
dc.subject.MESHPhenotype-
dc.subject.MESHStomach Neoplasms/blood*-
dc.subject.MESHStomach Neoplasms/genetics-
dc.subject.MESHStomach Neoplasms/mortality-
dc.titleAltered Expression of Lewis Antigen on Tissue and Erythrocytes in Gastric Cancer Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorMoon Jung Kim-
dc.contributor.googleauthorHan Soo Kim-
dc.contributor.googleauthorKyung Soon Song-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorYoung Ki Paik-
dc.contributor.googleauthorHyun Ok Kim-
dc.identifier.doi10.3349/ymj.2002.43.4.427-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01100-
dc.contributor.localIdA01122-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid12205729-
dc.subject.keywordLewis antigen-
dc.subject.keywordLewis genotype-
dc.subject.keywordgastric cancer-
dc.subject.keywordsialylation-
dc.contributor.alternativeNameKim, Han Soo-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Han Soo-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.rights.accessRightsfree-
dc.citation.volume43-
dc.citation.number4-
dc.citation.startPage427-
dc.citation.endPage434-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.43(4) : 427-434, 2002-
dc.identifier.rimsid57179-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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