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선단 흑자성 흑색종의 면역조직화학적 연구
DC Field | Value | Language |
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dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2016-05-16T11:19:00Z | - |
dc.date.available | 2016-05-16T11:19:00Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0494-4739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144280 | - |
dc.description.abstract | Background : Although clinicopathologic characteristics of acral lentiginous melanoma (ALM) is well established, immunohistohemical study on ALM has rarely been reported. Objective : Our purpose is to evaluate the usefulness of several immune markers in the diagnosis of ALM. Methods : An it immunohistochemical study was performed on paraffin sections of 20 ALMs using S-100 protein. HMB-45, vimentin, epithelial membrane antigen (EMA), and CAM 5.2. Results : 1. Nineteen (95%) and 16 (80%) out of 20 ALM showed reactivity with S-100 protein and HMB-45, respectively. 2. Melanin bleaching was useful for diagnosing heavily pigmented ALM using both S-100 protein and HMB-45. 3. The immunoreactivity of S-100 protein and HMB-45 did not correlate with tumor thickness or level of invasion of ALM. The intensity of HMB-45 correlated well with the melanin content. 4. One and 2 out of 20 cases stained totally with EMA and CAM5.2 respectively, but these cases stained also with HMB-45 and/or S-100 protein. Conclusion : S-100 protein and HMB-45 were relatively sensitive markers for diagnosing ALM. Despite the occasional positivity for he epithelial markers in ALM, all epithelial marker-punitive cases stained also with HMB-45 and/or S-100 protein. Therefore, S-100 protein and HMB-45 are very useful markers for diagnosing ALM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 620~625 | - |
dc.relation.isPartOf | Korean Journal of Dermatology (대한피부과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 선단 흑자성 흑색종의 면역조직화학적 연구 | - |
dc.title.alternative | Immunohistochemical Study on Acral Lentiginous Melanoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 김유찬 | - |
dc.contributor.googleauthor | 이민걸 | - |
dc.contributor.googleauthor | 조상호 | - |
dc.contributor.googleauthor | 최성환 | - |
dc.contributor.googleauthor | 박향준 | - |
dc.contributor.googleauthor | 신용우 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02779 | - |
dc.relation.journalcode | J02000 | - |
dc.subject.keyword | Acral lentiginous melanoma | - |
dc.subject.keyword | HMB-45 | - |
dc.subject.keyword | S-100 protein | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 620 | - |
dc.citation.endPage | 625 | - |
dc.identifier.bibliographicCitation | Korean Journal of Dermatology (대한피부과학회지), Vol.40(6) : 620-625, 2002 | - |
dc.identifier.rimsid | 57166 | - |
dc.type.rims | ART | - |
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