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국한성병기 소세포폐암 환자에서 조기 혹은 지연 교대 방사선-황암제치료의 전향적 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세규 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 이창걸 | - |
dc.date.accessioned | 2016-05-16T11:18:38Z | - |
dc.date.available | 2016-05-16T11:18:38Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144266 | - |
dc.description.abstract | Purpose: A randomized prospective study was conducted to compare the efficacy of early or late alternating schedules of radiotherapy, and carboplatin and ifosfamide chemotherapy in patients with limited-disease small cell lung cancer. Materials and Methods: From August 1993 to August 1996, a total of 44 patients with newly diagnosed, limited-disease small cell lung cancer, PS H0∼2, wt loss<10% were enrolled in a randomized trial which compared early alternating radiotherapy (RT)/chemotherapy (CT) and late alternating RT/CT. The CT regimen included ifosfamide 1.5 g/㎡ Ⅳ, d1-5 and carboplatin AUC 5/d Ⅳ, d2 performed at 4 week intervals for a total of 6 cycles. RT (54 ㏉/30 fr) was started after the first cycle of CT(early arm, N=22) or after the third cycle of CT (late arm, N=22) with a split course of treatment. Results: The pretreatment characteristics between the two arms were well balanced. The response rates in the early (86%) and late (85%) arm were similar. The median survival durations and 2-year survival rates were 15 months and 22.7% in the early arm, and 17 months and 14.9% in the late arm ( p=0.47 by the log-rank test). The two-year progression free survival rates were 19.1% in the early arm and 19.6% in the late arm ( p=0.52 by the log-rank test). Acute grade 3 or 4 hematologic and nonhematologic toxicities were similar between the two arms. Eighteen patients (82%) completed 6 cycles of CT in the early arm and 17 (77%) in the late arm. Four patients received less than 45 ㏉ of RT in the early arm and two in the late arm. There was no significant difference in the failure patterns. The local failure rate was 43% in the early arm and 45% in the late arm. The first site of failure was the brain in 24% of the early arm patients compared to 35% in the late arm ( p=0.51). Conclusion: There were no statistical differences in the overall survival rate and the pattern of failure between the early and late alternating RT/CT in patients with limited-disease small cell lung cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 116~122 | - |
dc.language | Korean | - |
dc.publisher | 대한방사선종양학회 | - |
dc.relation.isPartOf | Journal of the Korean Society for Therapeutic Radiology and Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 국한성병기 소세포폐암 환자에서 조기 혹은 지연 교대 방사선-황암제치료의 전향적 연구 | - |
dc.title.alternative | Randomized Trial of Early Versus Late Alternating Radiotherapy/ Chemotherapy in Limited-Disease Patients with Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | 이창걸 | - |
dc.contributor.googleauthor | 김주항 | - |
dc.contributor.googleauthor | 김성규 | - |
dc.contributor.googleauthor | 김세규 | - |
dc.contributor.googleauthor | 김귀언 | - |
dc.contributor.googleauthor | 서창옥 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00602 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A03240 | - |
dc.relation.journalcode | J01857 | - |
dc.subject.keyword | 소세포폐암 | - |
dc.subject.keyword | 교대 방사선-항암제치료 | - |
dc.contributor.alternativeName | Kim, Se Kyu | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Kim, Se Kyu | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 122 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Therapeutic Radiology and Oncology, Vol.20(2) : 116-122, 2002 | - |
dc.identifier.rimsid | 56719 | - |
dc.type.rims | ART | - |
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