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매독균의 혈관내피세포 표면 유착 및 투과 기전에 관한 연구
DC Field | Value | Language |
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dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2016-05-16T11:18:28Z | - |
dc.date.available | 2016-05-16T11:18:28Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1225-8180 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144259 | - |
dc.description.abstract | For T. pallidum to disseminate and cause systemic infection, it must traverse the endothelial cells lining the vasculature. In inflammatory and immune reactions, vascular endothelial cells act as key effectors. Fibronection appears to be important to T. pallidum cytadherence, because antifibronectin antibody prevents attachment of the T. pallidum to host cells and fibronectin-coated glass surfaces. We investigated the binding assay of T. pallidum to cultured human dermal microvascular endothelial cells (HDMEC) or fibronectin. We observed the adherence of T. pallidum to HDMEC and small percentage of adherent T. pallidum traverse through HDMEC monolayer, but the nonpathogenic treponemes and heat-inactivated T. pallidum failed to bind and trasverse to HDMEC. The adherence of T. pallidum to HDMEC was increased by a 47kDa antigen of T. pallidum of TNF-α. We also observed the adherence of T. pallidum to fibronectin. These findings suggest that only live pathogenic T. pallidum is capable of binds to HDMEC or fibronection and the binding of T. pallidum to HDMEC can be regulated by a 47kDa antigen of T. pallidum. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 165~170 | - |
dc.relation.isPartOf | Korean Journal of InvestigativeDermatology (대한피부연구학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 매독균의 혈관내피세포 표면 유착 및 투과 기전에 관한 연구 | - |
dc.title.alternative | A study of Adherence and Migration of Treponema pallidum through Endothelial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | 최현주 | - |
dc.contributor.googleauthor | 김경호 | - |
dc.contributor.googleauthor | 이주희 | - |
dc.contributor.googleauthor | 이민걸 | - |
dc.contributor.googleauthor | 이정복 | - |
dc.contributor.googleauthor | 이광훈 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02779 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J02042 | - |
dc.subject.keyword | T. pallidum | - |
dc.subject.keyword | 47kDa antigen | - |
dc.subject.keyword | Human dermal microvascular endothelial cells | - |
dc.subject.keyword | Fibronectin | - |
dc.subject.keyword | Migration | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 170 | - |
dc.identifier.bibliographicCitation | Korean Journal of InvestigativeDermatology (대한피부연구학회지), Vol.9(3) : 165-170, 2002 | - |
dc.identifier.rimsid | 56714 | - |
dc.type.rims | ART | - |
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