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The injured brain interacts reciprocally with scaffolds seeded with neural stem cells to reconstitute lost tissue.

DC Field Value Language
dc.contributor.author박국인-
dc.date.accessioned2016-05-16T11:18:14Z-
dc.date.available2016-05-16T11:18:14Z-
dc.date.issued2002-
dc.identifier.issn1087-0156-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144250-
dc.description.abstractHypoxic-ischemic injury is a prototype for insults characterized by extensive tissue loss. Seeding neural stem cells (NSCs) onto a polymer scaffold that was subsequently implanted into the infarction cavities of mouse brains injured by hypoxia-ischemia allowed us to observe the multiple reciprocal interactions that spontaneously ensue between NSCs and the extensively damaged brain: parenchymal loss was dramatically reduced, an intricate meshwork of many highly arborized neurites of both host- and donor-derived neurons emerged, and some anatomical connections appeared to be reconstituted. The NSC–scaffold complex altered the trajectory and complexity of host cortical neurites. Reciprocally, donor-derived neurons were seemingly capable of directed, target-appropriate neurite outgrowth (extending axons to the opposite hemisphere) without specific external instruction, induction, or genetic manipulation of host brain or donor cells. These “biobridges” appeared to unveil or augment a constitutive reparative response by facilitating a series of reciprocal interactions between NSC and host, including promoting neuronal differentiation, enhancing the elaboration of neural processes, fostering the re-formation of cortical tissue, and promoting connectivity. Inflammation and scarring were also reduced, facilitating reconstitution.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1111~1117-
dc.relation.isPartOfNATURE BIOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe injured brain interacts reciprocally with scaffolds seeded with neural stem cells to reconstitute lost tissue.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorKook In Park-
dc.contributor.googleauthorYang D. Teng-
dc.contributor.googleauthorEvan Y. Snyder-
dc.identifier.doi10.1038/nbt751-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01438-
dc.relation.journalcodeJ02290-
dc.identifier.eissn1546-1696-
dc.identifier.urlhttp://www.nature.com/nbt/journal/v20/n11/full/nbt751.html-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.rights.accessRightsnot free-
dc.citation.volume20-
dc.citation.number11-
dc.citation.startPage1111-
dc.citation.endPage1117-
dc.identifier.bibliographicCitationNATURE BIOTECHNOLOGY, Vol.20(11) : 1111-1117, 2002-
dc.identifier.rimsid56708-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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