Cited 504 times in
The injured brain interacts reciprocally with scaffolds seeded with neural stem cells to reconstitute lost tissue.
DC Field | Value | Language |
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dc.contributor.author | 박국인 | - |
dc.date.accessioned | 2016-05-16T11:18:14Z | - |
dc.date.available | 2016-05-16T11:18:14Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144250 | - |
dc.description.abstract | Hypoxic-ischemic injury is a prototype for insults characterized by extensive tissue loss. Seeding neural stem cells (NSCs) onto a polymer scaffold that was subsequently implanted into the infarction cavities of mouse brains injured by hypoxia-ischemia allowed us to observe the multiple reciprocal interactions that spontaneously ensue between NSCs and the extensively damaged brain: parenchymal loss was dramatically reduced, an intricate meshwork of many highly arborized neurites of both host- and donor-derived neurons emerged, and some anatomical connections appeared to be reconstituted. The NSC–scaffold complex altered the trajectory and complexity of host cortical neurites. Reciprocally, donor-derived neurons were seemingly capable of directed, target-appropriate neurite outgrowth (extending axons to the opposite hemisphere) without specific external instruction, induction, or genetic manipulation of host brain or donor cells. These “biobridges” appeared to unveil or augment a constitutive reparative response by facilitating a series of reciprocal interactions between NSC and host, including promoting neuronal differentiation, enhancing the elaboration of neural processes, fostering the re-formation of cortical tissue, and promoting connectivity. Inflammation and scarring were also reduced, facilitating reconstitution. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1111~1117 | - |
dc.relation.isPartOf | NATURE BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The injured brain interacts reciprocally with scaffolds seeded with neural stem cells to reconstitute lost tissue. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Kook In Park | - |
dc.contributor.googleauthor | Yang D. Teng | - |
dc.contributor.googleauthor | Evan Y. Snyder | - |
dc.identifier.doi | 10.1038/nbt751 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01438 | - |
dc.relation.journalcode | J02290 | - |
dc.identifier.eissn | 1546-1696 | - |
dc.identifier.url | http://www.nature.com/nbt/journal/v20/n11/full/nbt751.html | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.affiliatedAuthor | Park, Kook In | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 20 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1111 | - |
dc.citation.endPage | 1117 | - |
dc.identifier.bibliographicCitation | NATURE BIOTECHNOLOGY, Vol.20(11) : 1111-1117, 2002 | - |
dc.identifier.rimsid | 56708 | - |
dc.type.rims | ART | - |
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