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rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries

Authors
 Lishi Qian  ;  Chiyoji Abe  ;  Tao Ping Lin  ;  Ming Chih Yu  ;  Sang Nae Cho  ;  Sumin Wang  ;  James T. Douglas 
Citation
 JOURNAL OF CLINICAL MICROBIOLOGY, Vol.40(3) : 1091-1094, 2002 
Journal Title
 JOURNAL OF CLINICAL MICROBIOLOGY 
ISSN
 0095-1137 
Issue Date
2002
MeSH
DNA-Directed RNA Polymerases/genetics* ; Drug Resistance, Bacterial ; Genotype ; Mutation ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics* ; Rifampin/pharmacology
Abstract
The 81-bp region of the rpoB gene in 66 Rifr Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single-nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%, respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.
Files in This Item:
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DOI
10.1128/JCM.40.3.1091-1094.2002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Cho, Sang Nae(조상래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144226
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