Cited 42 times in
Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle
DC Field | Value | Language |
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dc.contributor.author | 이문형 | - |
dc.date.accessioned | 2016-05-16T11:17:19Z | - |
dc.date.available | 2016-05-16T11:17:19Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0363-6135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144215 | - |
dc.description.abstract | The effects of acute amiodarone infusion on dynamics of ventricular fibrillation (VF) are unclear. Six isolated swine right ventricles (RVs) were studied in vitro. Activation patterns during VF were mapped optically, whereas action potentials were recorded with a glass microelectrode. At baseline, VF was associated with frequent spontaneous wave breaks. Amiodarone (2.5 μg/ml) reduced spontaneous wave breaks and increased the cycle length (CL) of VF from 83.3 ± 17.8 ms at baseline to 118.4 ± 25.8 ms during infusion (P < 0.05). Amiodarone increased the reentrant wave front CL (114.4 ± 15.5 vs. 78.2 ± 19.0 ms, P < 0.05) and central core area (4.1 ± 3.8 vs. 0.9 ± 0.3 mm2, P < 0.05). Within 30 min of infusion, VF terminated (n = 1), converted to ventricular tachycardia (VT) (n = 1) or continued at a slower rate (n = 4). Amiodarone flattened the APD restitution curves. We conclude that amiodarone reduced spontaneous wave breaks. It might terminate VF or convert VF to VT. These effects were associated with the flattening of APD restitution slope and increased core size of reentrant wave fronts. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | H1063~H1070 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Action Potentials/drugeffects | - |
dc.subject.MESH | Action Potentials/physiology | - |
dc.subject.MESH | Amiodarone/pharmacology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Arrhythmia Agents/pharmacology* | - |
dc.subject.MESH | Diastole/drugeffects | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Membrane Potentials/drugeffects | - |
dc.subject.MESH | Membrane Potentials/physiology | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | VentricularFibrillation/physiopathology* | - |
dc.subject.MESH | VentricularFunction,Right/drugeffects | - |
dc.subject.MESH | VentricularFunction,Right/physiology* | - |
dc.title | Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chikaya Omichi | - |
dc.contributor.googleauthor | Shengmei Zhou | - |
dc.contributor.googleauthor | Moon Hyoung Lee | - |
dc.contributor.googleauthor | Ajay Naik | - |
dc.contributor.googleauthor | Che Ming Chang | - |
dc.contributor.googleauthor | Alan Garfinkel | - |
dc.contributor.googleauthor | James N. Weiss | - |
dc.contributor.googleauthor | Shien Fong Lin | - |
dc.contributor.googleauthor | Hrayr S. Karagueuzian | - |
dc.contributor.googleauthor | Peng Sheng Chen | - |
dc.identifier.doi | 10.1152/ajpheart.00633.2001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02766 | - |
dc.relation.journalcode | J00105 | - |
dc.identifier.eissn | 1522-1539 | - |
dc.identifier.pmid | 11834505 | - |
dc.subject.keyword | action potential duration restitution | - |
dc.subject.keyword | sudden death | - |
dc.subject.keyword | pharmacology | - |
dc.subject.keyword | antiarrhythmic agents | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 282 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1063 | - |
dc.citation.endPage | 1070 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol.282(3) : 1063-1070, 2002 | - |
dc.identifier.rimsid | 56689 | - |
dc.type.rims | ART | - |
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