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Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2
DC Field | Value | Language |
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dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2016-05-16T11:17:09Z | - |
dc.date.available | 2016-05-16T11:17:09Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144209 | - |
dc.description.abstract | Factor Xa-induced stimulation of coronary artery smooth muscle cells (CASMC) was investigated by analyzing [3H]thymidine incorporation, cell proliferation, and ERK-1/2 activation. Exposure of the cells to factor Xa evoked a time-dependent activation of ERK-1/2 with increased [3H]thymidine incorporation and cell proliferation. The factor Xa-induced ERK-1/2 activation was not desensitized by preincubation of the cells with thrombin. However, ERK-1/2 activation was markedly attenuated by prior exposure of the cells to protease-activated receptor-2 (PAR-2) activating peptide, SLIGKV. The mitogenic effect of factor Xa was significantly reduced in the presence of anti-PAR-2 monoclonal antibody. Several lines of experimental evidence indicate that factor Xa-induced mitogenesis of CASMC is a cellular process mediated by PAR-2 activation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 85~89 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Factor Xa induces mitogenesis of coronary artery smooth muscle cell via activation of PAR-2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Bon-Hun Koo | - |
dc.contributor.googleauthor | Kwang-Hoe Chung | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Doo-Sik Kim | - |
dc.identifier.doi | 10.1016/S0014-5793(02)02948-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.subject.keyword | Coronary artery smooth muscle cell | - |
dc.subject.keyword | Factor Xa | - |
dc.subject.keyword | Protease-activated receptor-2 | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 523 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 89 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.523(1-3) : 85-89, 2002 | - |
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