Cited 10 times in
Effect of Rebamipide in Treatment of Helicobacter pylori-Associated Duodenal Ulcer;Attenuation of Chemokine Expression and Nitrosative Damage
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용찬 | - |
dc.date.accessioned | 2016-05-16T11:17:04Z | - |
dc.date.available | 2016-05-16T11:17:04Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144206 | - |
dc.description.abstract | Production of cytokines along with increased activity of nitric oxide synthase has been implicated as one of the contributing mechanisms of Helicobacter pylori-mediated gastroduodenal diseases. We aimed to evaluate the effect of rebamipide in treating Helicobacter pylori-associated duodenal ulcers in terms of cytokine production and nitrosative damage of the gastric mucosa. In patients with duodenal ulcers, rebamipide or placebo were given randomly after eradication. Mucosal cytokine production was measured by enzyme linked immunoassay, and nitrotyrosine immunoexpression was measured by immunohistochemistry. The inflammatory activity and degree of neutrophil infiltration were graded accordingly. The mucosal production of RANTES, interleukin-8, and TNF-α showed a significant decrease after eradication in patients with rebamipide after-treatment. The nitrotyrosine immunoreactivity of gastric epithelium was significantly decreased in the rebamipide group. Rebamipide treatment after eradication resulted in a significant reduction in chemokine production along with nitrotyrosine immunoexpression in Helicobacter pylori-associated duodenal ulcers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 283~291 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alanine/analogs & derivatives* | - |
dc.subject.MESH | Alanine/therapeutic use* | - |
dc.subject.MESH | Antioxidants/therapeutic use* | - |
dc.subject.MESH | ChemokineCCL5/biosynthesis | - |
dc.subject.MESH | Cytokines/biosynthesis* | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | DuodenalUlcer/drug therapy* | - |
dc.subject.MESH | DuodenalUlcer/metabolism | - |
dc.subject.MESH | DuodenalUlcer/microbiology* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gastric Mucosa/metabolism* | - |
dc.subject.MESH | HelicobacterInfections/complications* | - |
dc.subject.MESH | HelicobacterInfections/drug therapy | - |
dc.subject.MESH | HelicobacterInfections/metabolism | - |
dc.subject.MESH | Helicobacterpylori* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Interleukin-1/biosynthesis | - |
dc.subject.MESH | Interleukin-8/biosynthesis | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Quinolones/therapeutic use* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/biosynthesis | - |
dc.subject.MESH | Tyrosine/analogs & derivatives* | - |
dc.subject.MESH | Tyrosine/biosynthesis | - |
dc.title | Effect of Rebamipide in Treatment of Helicobacter pylori-Associated Duodenal Ulcer;Attenuation of Chemokine Expression and Nitrosative Damage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | K.W. Choi | - |
dc.contributor.googleauthor | Y.C. Lee | - |
dc.contributor.googleauthor | I.S. Chung | - |
dc.contributor.googleauthor | J.J. Lee | - |
dc.contributor.googleauthor | M.H. Chung | - |
dc.contributor.googleauthor | N.Y. Kim | - |
dc.contributor.googleauthor | S.W. Kim | - |
dc.contributor.googleauthor | J.G. Kim | - |
dc.contributor.googleauthor | I.H. Roe | - |
dc.contributor.googleauthor | S.W. Lee | - |
dc.contributor.googleauthor | H.Y. Jung | - |
dc.contributor.googleauthor | M.G. Choi | - |
dc.contributor.googleauthor | K.B. Hahm | - |
dc.contributor.googleauthor | W.S. Hong | - |
dc.contributor.googleauthor | J.H. Kim | - |
dc.identifier.doi | 10.1023/A:1013753602149 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02988 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 11855542 | - |
dc.identifier.url | http://link.springer.com/article/10.1023/A%3A1013753602149 | - |
dc.subject.keyword | rebamipide | - |
dc.subject.keyword | cytokines | - |
dc.subject.keyword | nitrosative damages | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 283 | - |
dc.citation.endPage | 291 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.47(2) : 283-291, 2002 | - |
dc.identifier.rimsid | 56682 | - |
dc.type.rims | ART | - |
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