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Genetic contribution to factor VII levels in families of patients undergoing coronary arteriography
DC Field | Value | Language |
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dc.contributor.author | 서일 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2016-05-16T11:17:00Z | - |
dc.date.available | 2016-05-16T11:17:00Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0957-5235 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144203 | - |
dc.description.abstract | An elevated plasma level of factor VII is a risk factor for coronary artery disease. We investigated environmental, familial, and genetic influences on factor VII activity in 508 family members of 87 probands who underwent elective coronary arteriography. Maximum likelihood methods were used to fit several genetic and non-genetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of factor VII. Factor VII activities were adjusted for age, gender, body mass index, smoking, alcohol consumption, menopause status, and triglycerides prior to this segregation analysis (this model accounted for 33.5% of the total variation). Adjusted factor VII activities showed strong familial aggregation with an estimated parent–offspring correlation of 0.34, sibling correlation of 0.36 and a smaller spouse correlation of 0.16. Regressive models were used to test genetic and non-genetic models in these 87 families. Mendelian single-locus models with either two or three underlying genotypic distributions of factor VII activities were best supported by these data. Essentially, these Mendelian models suggest most individuals come from a low distribution (mean, 116%), with a few individuals homozygous for a high allele drawn from a distribution with a mean of 166%. Future linkage studies may be worthwhile to further clarify the mechanisms controlling factor VII activity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 25~33 | - |
dc.relation.isPartOf | BLOOD COAGULATION & FIBRINOLYSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Angiography | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | CoronaryAngiography | - |
dc.subject.MESH | CoronaryArtery Disease/diagnosis | - |
dc.subject.MESH | CoronaryArtery Disease/genetics* | - |
dc.subject.MESH | FactorVII/genetics* | - |
dc.subject.MESH | FactorVII/metabolism | - |
dc.subject.MESH | FamilyHealth | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | GeneticPredisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models,Genetic* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | RiskFactors | - |
dc.title | Genetic contribution to factor VII levels in families of patients undergoing coronary arteriography | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | S.H. Jee | - |
dc.contributor.googleauthor | K.S. Song | - |
dc.contributor.googleauthor | W. Shim | - |
dc.contributor.googleauthor | H.K. Kim | - |
dc.contributor.googleauthor | I. Suh | - |
dc.contributor.googleauthor | Y. Yoon | - |
dc.contributor.googleauthor | T. H. Beaty | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01899 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00343 | - |
dc.identifier.eissn | 1473-5733 | - |
dc.identifier.pmid | 11994564 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001721-200201000-00004&LSLINK=80&D=ovft | - |
dc.subject.keyword | actor VII activity | - |
dc.subject.keyword | segregation analysis | - |
dc.contributor.alternativeName | Suh, Il | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Suh, Il | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 25 | - |
dc.citation.endPage | 33 | - |
dc.identifier.bibliographicCitation | BLOOD COAGULATION & FIBRINOLYSIS, Vol.13(1) : 25-33, 2002 | - |
dc.identifier.rimsid | 56680 | - |
dc.type.rims | ART | - |
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