0 127

Cited 0 times in

Correlation between myocardial perfusion abnormalities detected with intermittent imaging using intravenous perfluorocarbon microbubbles and radioisot

Authors
 Ricardo E. Ronderos  ;  Mario Boskis  ;  Namsik Chung  ;  Diomedes B. Corneli  ;  Eduardo M. Escudero  ;  Jong W. Ha  ;  Carlos Charlante  ;  Se Joon Rim  ;  Marcelo Portis  ;  Nora Fabris  ;  Jorge Camilletti  ;  Anibal A. Mele  ;  Fernando Otero  ;  Thomas R. Porter 
Citation
 CLINICAL CARDIOLOGY, Vol.25(3) : 103-111, 2002 
Journal Title
 CLINICAL CARDIOLOGY 
ISSN
 0160-9289 
Issue Date
2002
MeSH
Adult ; Aged ; Aged, 80 and over ; Contrast Media ; Coronary Circulation/physiology* ; Coronary Disease/diagnostic imaging* ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/ultrastructure ; Dipyridamole* ; Echocardiography/methods ; Female ; Fluorocarbons* ; Humans ; Injections, Intravenous ; Male ; Middle Aged ; Observer Variation ; Prospective Studies ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon/methods
Keywords
contrast echo ; stress echo ; myocardial ischemia ; ultrasound contrast agents ; dipyridamole contrast echo
Abstract
Background: The clinical accuracy of myocardial contrast echocardiography (MCE) using intermittent harmonic imaging and intravenous perfluorocarbon containing microbubbles during dipyridamole stress has not been evaluated in a multi-center setting. Hypothesis: The accuracy of dipyridamole stress contrast echo in the detection of coronary artery disease (CAD) using myocardial perfusion images is high in comparison with tech-netium-99 (99Tc) sestamibi single-photon emission computed tomography (MIBI SPECT) and increases the accuracy of wall motion data. Methods: In 68 consecutive nonselected patients (46 men; mean age 66 years) from three different institutions in two countries, dipyridamole stress echo and SPECT with 99mTc MIBI were compared. Continuous intravenous (IV) infusion of perfluorocarbon exposed sonicated dextrose albumin (PES-DA) (2-5 cc/min) was administered for baseline myocardial perfusion using triggered harmonic end systolic frames. Realtime digitized images were used for wall motion analysis. Dipyridamole was then injected in two steps: (1) 0.56 mg/kg for 3 min; (2) 0.28 mg/kg for 1 min, if the first step was negative for an inducible wall motion abnormality. After dipyridamole injection, myocardial contrast enhancement and wall motion were analyzed again by the same methodology. Results: There were 35 patients with perfusion defects by SPECT. Wall motion was abnormal in 22, while MCE was abnormal in 32. Wall motion and MCE each had one false positive. The proportion of correctly assigned patients was significantly better with MCE than with wall motion (p = 0.03; chi square test). Conclusions: Myocardial contrast echocardiography, using intermittent harmonic imaging and intravenous perfluorocarbon containing microbubbles, is a very effective method for detecting coronary artery disease during dipyridamole stress echo.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/clc.4960250305/abstract
DOI
10.1002/clc.4960250305
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144173
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse