Cited 80 times in
Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study.
DC Field | Value | Language |
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dc.contributor.author | 이준수 | - |
dc.date.accessioned | 2016-05-16T11:16:11Z | - |
dc.date.available | 2016-05-16T11:16:11Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0148-639X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144172 | - |
dc.description.abstract | The basis for cognitive impairment in Duchenne muscular dystrophy (DMD) is not well understood but may be related to abnormal expression of dystrophin in brain. The aim of this study was to determine whether regional brain glucose metabolism is altered in children with DMD and whether such metabolic disturbances are localized to regions shown to be normally rich in dystrophin expression. Ten boys (mean age, 11.8 years) with DMD and 17 normal adults as a control group (mean age, 27.6 years) underwent 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography (PET) and neuropsychological evaluation. The PET data were analyzed by statistical parametric mapping (SPM). The SPM analysis showed five clusters of decreased glucose metabolism in children with DMD, including the medial temporal structures and cerebellum bilaterally and the sensorimotor and lateral temporal cortex on the right side. At the voxel level, significant glucose hypometabolism was found in the right postcentral and middle temporal gyri, uncus, and VIIIB cerebellar lobule, as well as in the left hippocampal gyrus and cerebellar lobule. The neuropsychological profile of the DMD group revealed borderline nonverbal intellectual functioning, impaired manual dexterity bilaterally, borderline cognitive functioning, and internalizing behavioral difficulties. Our findings demonstrate region-specific hypometabolism, as well as cognitive and behavioral deficits in DMD children. As the regions showing hypometabolism on PET include those normally rich in dystrophin expression, it will be important to determine whether the hypometabolic regions also show cytoarchitectural abnormalities related to the lack of dystrophin. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26:506-512, 2002 | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 506~512 | - |
dc.relation.isPartOf | MUSCLE & NERVE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Brain/diagnostic imaging | - |
dc.subject.MESH | BrainChemistry/physiology* | - |
dc.subject.MESH | BrainMapping | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cognition/physiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18 | - |
dc.subject.MESH | Glucose/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | MuscularDystrophy,Duchenne/diagnostic imaging | - |
dc.subject.MESH | MuscularDystrophy,Duchenne/metabolism* | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.subject.MESH | Psychomotor Performance/physiology | - |
dc.subject.MESH | Radiopharmaceuticals | - |
dc.subject.MESH | Tomography, Emission-Computed | - |
dc.title | Altered regional brain glucose metabolism in Duchenne muscular dystrophy: a pet study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Zoltán Pfund | - |
dc.contributor.googleauthor | Csaba Juhász | - |
dc.contributor.googleauthor | Michael E. Behen | - |
dc.contributor.googleauthor | Otto Muzik | - |
dc.contributor.googleauthor | Diane C. Chugani | - |
dc.contributor.googleauthor | Michael A. Nigro | - |
dc.contributor.googleauthor | Harry T. Chugani | - |
dc.identifier.doi | 10.1002/mus.10238 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03177 | - |
dc.relation.journalcode | J02278 | - |
dc.identifier.eissn | 1097-4598 | - |
dc.identifier.pmid | 12362416 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/mus.10238/abstract | - |
dc.subject.keyword | brain glucose metabolism | - |
dc.subject.keyword | Duchenne muscular dystrophy | - |
dc.subject.keyword | neuropsychological assessment | - |
dc.subject.keyword | positron emission tomography | - |
dc.subject.keyword | statistical parametric mapping | - |
dc.contributor.alternativeName | Lee, Joon Soo | - |
dc.contributor.affiliatedAuthor | Lee, Joon Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 506 | - |
dc.citation.endPage | 512 | - |
dc.identifier.bibliographicCitation | MUSCLE & NERVE, Vol.26(4) : 506-512, 2002 | - |
dc.identifier.rimsid | 56657 | - |
dc.type.rims | ART | - |
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