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c-Myc exerts a protective function through ornithine decarboxylase against cellular insults

DC Field Value Language
dc.contributor.author김형중-
dc.date.accessioned2016-05-16T11:16:09Z-
dc.date.available2016-05-16T11:16:09Z-
dc.date.issued2002-
dc.identifier.issn0026-895X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144171-
dc.description.abstractc-Myc is known to control cell proliferation and apoptosis, and much effort has been focused on elucidating the mechanisms by which c-Myc works. In this study, we show that c-Myc expression is induced by many cellular insults, including cisplatin, doxorubicin, paclitaxel, 5-flourouracil, H2O2, and radiation, and the enhanced expression of c-Myc protects against cell death caused by these cellular insults through ornithine decarboxylase (ODC) induction. To investigate the cellular protective role of c-Myc, we constructed a stable transfectant of ODC, one of the many transcriptional targets of c-Myc in cells, and found that enhanced expression of ODC inhibited cell death induced by cellular insults such as cisplatin, H2O2, and radiation. We also found that cisplatin activated nuclear factor-κB, and this subsequently induced c-Myc expression, resulting in the blocking of apoptosis through ODC induction. The results herein, therefore, strongly suggest another role for c-Myc in a stress-response function; that is, it promotes cell survival under stressful conditions.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1400~1408-
dc.relation.isPartOfMOLECULAR PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntineoplastic Agents/pharmacology-
dc.subject.MESHCell Survival/physiology-
dc.subject.MESHCisplatin/pharmacology-
dc.subject.MESHEnzyme Induction-
dc.subject.MESHGene Expression/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHNF-kappa B/metabolism-
dc.subject.MESHOrnithineDecarboxylase/biosynthesis*-
dc.subject.MESHOrnithineDecarboxylase/metabolism-
dc.subject.MESHProto-Oncogene Proteinsc-myc/genetics-
dc.subject.MESHProto-Oncogene Proteinsc-myc/physiology*-
dc.subject.MESHTumor Cells, Cultured-
dc.titlec-Myc exerts a protective function through ornithine decarboxylase against cellular insults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJong Kuk Park-
dc.contributor.googleauthorYoung Min Chung-
dc.contributor.googleauthorSeongman Kang-
dc.contributor.googleauthorJae Uk Kim-
dc.contributor.googleauthorYun Taik Kim-
dc.contributor.googleauthorHyung Jung Kim-
dc.contributor.googleauthorYeul Hong Kim-
dc.contributor.googleauthorJun Suk Kim-
dc.contributor.googleauthorYoung Do Yoo-
dc.identifier.doi10.1124/mol.62.6.1400-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01158-
dc.relation.journalcodeJ02267-
dc.identifier.eissn1521-0111-
dc.identifier.pmid12435808-
dc.subject.keywordCDDP-
dc.subject.keywordcis-diamminedichloroplatinum(II)-
dc.subject.keywordHDF-
dc.subject.keywordhuman dental fibroblast-
dc.subject.keywordRPE-
dc.subject.keywordretinal pigment epithelial-
dc.subject.keywordNF- B-
dc.subject.keywordnuclear factor- B-
dc.subject.keywordODC-
dc.subject.keywordornithine decarboxylase-
dc.subject.keyword5-FU-
dc.subject.keyword5-flourouracil-
dc.subject.keywordROS-
dc.subject.keywordreactive oxygen species-
dc.subject.keywordGy-
dc.subject.keywordgray-
dc.subject.keywordGAPDH-
dc.subject.keywordglyceraldehyde-3-phosphate dehydrogenase-
dc.subject.keywordEMSA-
dc.subject.keywordelectrophoretic mobility shift assay-
dc.subject.keywordPI, propidium iodide-
dc.subject.keywordJNKDD-
dc.subject.keyworddominant-negative c-Jun NH2-terminal kinase-1 mutant-
dc.subject.keywordI BDD-
dc.subject.keyworddominant-negative of I B mutant-
dc.subject.keywordkbp-
dc.subject.keywordkilobase pair-
dc.contributor.alternativeNameKim, Hyung Jung-
dc.contributor.affiliatedAuthorKim, Hyung Jung-
dc.rights.accessRightsfree-
dc.citation.volume62-
dc.citation.number6-
dc.citation.startPage1400-
dc.citation.endPage1408-
dc.identifier.bibliographicCitationMOLECULAR PHARMACOLOGY, Vol.62(6) : 1400-1408, 2002-
dc.identifier.rimsid56656-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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