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Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with mocrosatellite instability

DC FieldValueLanguage
dc.contributor.author김주항-
dc.contributor.author김호근-
dc.contributor.author이진성-
dc.date.accessioned2016-05-16T11:13:42Z-
dc.date.available2016-05-16T11:13:42Z-
dc.date.issued2002-
dc.identifier.issn0950-9232-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144078-
dc.description.abstractSomatic frameshift mutations in some genes containing coding mononucleotide repeats (cMNRs) are well known characteristics of tumors with high microsatellite instability (MSI-H). We identified 22 novel and 11 known target genes containing cMNRs with a length of 10 or more nucleotides by using a systematic database search. Frameshift mutation analysis was performed with these 33 genes in 39 MSI-H and 24 microsatellite stable (MSS) colorectal carcinomas by assessing the mobility shifts of PCR products in gel electrophoresis and by sequencing. All the 39 MSI-H colorectal carcinomas, except one, showed mutations in more than one gene, while no mutations were found in 24 MSS colorectal carcinomas. Of these MSI-H tumors, 11 genes were mutated in more than 40%. The most frequently mutated novel genes were MARCKS (72%), FLJ11383 (74%) and TAF1B (82%). Biallelic inactivation in MARCKS and FLJ11383 was also frequent in MSI-H tumors. The observed mutation frequency of the 11 known target genes was compatible with that found by previous studies. The very high frequency of mutations, biallelic mutations and the predicted truncation of protein products suggests that mutations of MARCKS, FLJ11383 and TAF1B are selected, and play a role in the tumorigenesis of MSI-H colorectal carcinomas.-
dc.description.statementOfResponsibilityopen-
dc.format.extent5081~5087-
dc.relation.isPartOfONCOGENE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBase Sequence-
dc.subject.MESHColorectal Neoplasms/genetics*-
dc.subject.MESHDNA Mutational Analysis-
dc.subject.MESHDNA, Neoplasm/genetics-
dc.subject.MESHDNA-Binding Proteins/genetics*-
dc.subject.MESHDatabases, Nucleic Acid-
dc.subject.MESHFrameshift Mutation-
dc.subject.MESHGlucosidases-
dc.subject.MESHHumans-
dc.subject.MESHIntracellular Signaling Peptides and Proteins*-
dc.subject.MESHMembrane Proteins*-
dc.subject.MESHMicrosatellite Repeats/genetics*-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHMutagenesis/genetics*-
dc.subject.MESHMyristoylated Alanine-Rich C Kinase Substrate-
dc.subject.MESHNeoplasm Proteins/genetics*-
dc.subject.MESHPhosphoproteins/genetics*-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHTerminal Repeat Sequences-
dc.subject.MESHTumor Cells, Cultured-
dc.titleIdentification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with mocrosatellite instability-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorNam Gyun Kim-
dc.contributor.googleauthorHwanseok Rhee-
dc.contributor.googleauthorLong Shan Li-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorJin Sung Lee-
dc.contributor.googleauthorJoo Hang Kim-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorHoguen Kim-
dc.identifier.doi10.1038/sj.onc. 1205703-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00945-
dc.contributor.localIdA01183-
dc.contributor.localIdA03227-
dc.relation.journalcodeJ02413-
dc.identifier.eissn1476-5594-
dc.identifier.pmid12140758-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameLee, Jin Sung-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorLee, Jin Sung-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number33-
dc.citation.startPage5081-
dc.citation.endPage5087-
dc.identifier.bibliographicCitationONCOGENE, Vol.21(33) : 5081-5087, 2002-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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