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Steroid hormone metabolism in women with pelvic organ prolapse

DC Field Value Language
dc.contributor.author배상욱-
dc.contributor.author김상운-
dc.contributor.author김세광-
dc.contributor.author나군호-
dc.date.accessioned2016-05-16T11:13:16Z-
dc.date.available2016-05-16T11:13:16Z-
dc.date.issued2002-
dc.identifier.issn0024-7758-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144062-
dc.description.abstractOBJECTIVE: To identify whether endogenous steroid hormone metabolism in women with pelvic organ prolapse (POP) is different from that in normal women and the relationship between endogenous steroid hormone metabolites and POP stage. STUDY DESIGN: Twenty postmenopausal women who were clinically diagnosed as having POP and 20 volunteer postmenopausal women without prolapse were included in the study. We compared the urinary profiles of endogenous steroids between the two groups and investigated the relationship between urinary profiles of endogenous steroids and degree of prolapse. Urinary profiles of endogenous steroids were assayed by gas chromatography/mass spectrometry. RESULTS: The ages of the patients and control group were 64.6±6.5 and 63.5±3.9 years, and the body mass index was 23.96±3.14 and 24.11±2.73 kg/m2 in patients and normal subjects, respectively. The number of patients were 4 at stage I, 4 at stage II, 6 at stage III and 6 at stage IV. 5-Androstene-3b,16b,17b-triol (5-AT), 11b-hydroxy an and 17b-estradiol were significantly increased in the POP group as compared with the control group (0.76±0.67 vs. 0.06±0.03 mmol/g creatinine, P=.002, 1.16±0.83 vs. 0.65±0.23 mmol/g creatinine, P=.04; and 15.08±9.81 vs. 8.53±6.19 mmol/g creatinine, P=.04). However, tetrahydrocortisone (THE) was significantly increased in the control group as compared with the patient group (9.80±6.21 vs. 5.22±4.89 mmol/g creatinine, P=.04). Androgen metabolites 5-AT and THE significantly correlated with the pelvic organ prolapse quantitation (POP-Q) stage (R=.418; P=.027; R=.46, P=.016). Among the estrogen metabolites, 17 b-estradiol correlated with POP-Q stage, but not significantly so (R=.38, P=.05), and the 17b-estradiol/estrone ratio weakly correlated with stage (R=.14, P=.49). CONCLUSION: The metabolites of endogenous steroid hormones could be contributing factors in the pathogenesis of POP. (J Reprod Med 2002;47:303-308)-
dc.description.statementOfResponsibilityopen-
dc.format.extent303~308-
dc.relation.isPartOfJOURNAL OF REPRODUCTIVE MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBody Mass Index-
dc.subject.MESHFemale-
dc.subject.MESHGas Chromatography-Mass Spectrometry-
dc.subject.MESHGonadal Steroid Hormones/metabolism*-
dc.subject.MESHGonadal Steroid Hormones/urine-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRisk Factors-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSteroids/metabolism*-
dc.subject.MESHSteroids/urine-
dc.subject.MESHUterine Prolapse/etiology-
dc.subject.MESHUterine Prolapse/metabolism*-
dc.subject.MESHUterine Prolapse/urine-
dc.titleSteroid hormone metabolism in women with pelvic organ prolapse-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorSang Wook Bai-
dc.contributor.googleauthorByung Hwa Jung-
dc.contributor.googleauthorBong Chul Chung-
dc.contributor.googleauthorSang Un Kim-
dc.contributor.googleauthorJeong Yeon Kim-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorSei Kwang Kim-
dc.contributor.googleauthorKi Hyun Park-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01793-
dc.contributor.localIdA00526-
dc.contributor.localIdA00601-
dc.contributor.localIdA01227-
dc.relation.journalcodeJ01736-
dc.identifier.pmid12012882-
dc.identifier.urlhttp://www.reproductivemedicine.com/toc/auto_abstract.php?id=16090-
dc.subject.keywordsteroids-
dc.subject.keywordhormones-
dc.subject.keyworduterine prolapse-
dc.subject.keywordvaginal prolapse-
dc.contributor.alternativeNameBai, Sang Wook-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sei Kwang-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.affiliatedAuthorBai, Sang Wook-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Sei Kwang-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.rights.accessRightsnot free-
dc.citation.volume47-
dc.citation.number4-
dc.citation.startPage303-
dc.citation.endPage308-
dc.identifier.bibliographicCitationJOURNAL OF REPRODUCTIVE MEDICINE, Vol.47(4) : 303-308, 2002-
dc.identifier.rimsid55555-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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