0 212

Cited 0 times in

Segregation analysis of waist circumference, hip circumference and waist-to-hip ratio in the Korean Nationwide Family Study

Authors
 S H Jee  ;  M T Kim  ;  S Y Lee  ;  T H Beaty 
Citation
 INTERNATIONAL JOURNAL OF OBESITY, Vol.26(2) : 228-233, 2002 
Journal Title
INTERNATIONAL JOURNAL OF OBESITY
ISSN
 0307-0565 
Issue Date
2002
MeSH
Adipose Tissue ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anthropometry ; Asian Continental Ancestry Group/genetics* ; Body Constitution/genetics* ; Child ; Family Health ; Female ; Health Surveys ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Obesity/genetics* ; Regression Analysis
Keywords
waist ; hip ; waist-to-hip ratio ; segregation analysis
Abstract
AIM: A central distribution of adipose tissue is frequently associated with cardiovascular disease and its risk factors. In this study, we investigated environmental, familial and genetic influences on waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) in 2507 members of 435 families who had participated in the Korean Nationwide Health Examination Survey. METHOD: Maximum likelihood methods were used to fit several genetic and nongenetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of WC, HC and WHR. Adjustments for age, age(2), body mass index, smoking, alcohol consumption and exercise were carried out separately for males and females by multiple regression procedures for WC, HC and WHR phenotypes prior to segregation analysis. Regression models were used to test genetic and non-genetic models in these 435 families. RESULTS: Segregation analysis did not provide statistical evidence of a major gene controlling either HC or WHR. Mendelian single-locus models with two underlying genotypic distributions were best supported by these data on WC, and this putative major gene explained the 22.4% of variance in adjusted WC. CONCLUSION: Future linkage studies may be worthwhile to further clarify the mechanisms controlling WC.
Full Text
http://www.nature.com/ijo/journal/v26/n2/full/0801884a.html
DOI
10.1038/sj/ijo/0801884
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143955
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links