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Epigallocatechin-3-Gallate Inhibits Basic Fibroblast Growth Factor-Induced Intracellular Signaling Transduction Pathway in Rat Aortic Smooth Muscle Ce
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2016-05-16T11:09:45Z | - |
dc.date.available | 2016-05-16T11:09:45Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0160-2446 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143928 | - |
dc.description.abstract | Daily green tea drinking showed preventive effects on the progression of atherosclerosis. Although epigallocatechin-3-gallate [EGCG] has anti-proliferative effects on various cells, relatively little is known about the molecular mechanisms of the anti-proliferative effects of EGCG. To determine whether the transduction signals and protooncogene expression were affected by EGCG, this study investigated the molecular mechanism of the anti-proliferative effects in basic fibroblast growth factor (bFGF)-stimulated rat aortic smooth muscle cells (RAoSMCs). EGCG inhibited the proliferative response stimulated by 10% fetal bovine serum dose dependently in RAoSMCs (median inhibitory concentration [IC 50 ]: 28.4 × 10 −6M). EGCG also inhibited the migration of bFGF-stimulated RAoSMCs in a dose-dependent manner, showing that 21.8 × 10 −6M of EGCG significantly inhibited the migration by 75 ± 5% in comparison with bFGF-stimulated migration. In RAoSMCs, EGCG dramatically inhibited Ras activation and c-jun N-terminal kinase (JNK) activity without affecting protein kinase C expression. Induction of c-jun mRNA stimulated by bFGF was significantly reduced dose dependently up to 87.3 × 10– 6M of EGCG. These results indicate that the anti-proliferative effect of EGCG on RAoSMCs is partly Ras/JNK mediated, independent of protein kinase C, and is attributable to the downregulation of c-jun expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 271~277 | - |
dc.relation.isPartOf | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Epigallocatechin-3-Gallate Inhibits Basic Fibroblast Growth Factor-Induced Intracellular Signaling Transduction Pathway in Rat Aortic Smooth Muscle Ce | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ki Chul Hwang | - |
dc.contributor.googleauthor | Kyung Hye Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Yeo Pyo Yun | - |
dc.contributor.googleauthor | Kwang Hoe Chung | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J01296 | - |
dc.identifier.eissn | 1533-4023 | - |
dc.identifier.url | http://journals.lww.com/cardiovascularpharm/Abstract/2002/02000/Epigallocatechin_3_Gallate_Inhibits_Basic.14.aspx | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 271 | - |
dc.citation.endPage | 277 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Vol.39(2) : 271-277, 2002 | - |
dc.identifier.rimsid | 39516 | - |
dc.type.rims | ART | - |
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