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Induction of telomerase activity during an early burst of proliferation in pancreatic regeneration

Authors
 Bong Kyeong Oha  ;  Je Kyung Seong  ;  Jeung Eun Lee  ;  Kwang Jo Chae  ;  Kyung Jin Roh  ;  Chanil Park  ;  Young Nyun Park 
Citation
 CANCER LETTERS, Vol.186(1) : 93-98, 2002 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
2002
MeSH
Amylases/blood ; Animals ; Blood Glucose/analysis ; DNA-Binding Proteins ; Enzyme Induction ; Male ; Pancreas/cytology ; Pancreas/enzymology* ; Pancreas/physiology* ; Proliferating Cell Nuclear Antigen/analysis ; RNA, Messenger/analysis ; Rats ; Rats, Sprague-Dawley ; Regeneration/physiology* ; Reverse Transcriptase Polymerase Chain Reaction ; Telomerase/biosynthesis* ; Telomerase/genetics
Keywords
Pancreas ; Regeneration ; Telomerase ; Telomerase reverse transcriptase ; Proliferation ; Pancreatectomy
Abstract
Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague–Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase–polymerase chain reaction. TA increased at 2 days and reached a maximum at 3 days after px, when the small ductules showed the highest proliferation activity. After 3 days, TA decreased to basal levels as the ductules differentiated into new endocrine and exocrine pancreas. The expression of rTERT showed a correlation with TA. These results suggest telomerase is actively regulated during pancreatic regeneration.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304383502003208
DOI
10.1016/S0304-3835(02)00320-8
Appears in Collections:
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Chan Il(박찬일)
Oh, Bong Kyeong(오봉경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143924
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