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Clinicopathologic Review of Pulmonary Silicone Embolism with Special Emphasis on the Resultant Histologic Diversity in the Lung: A Review of Five Cases

Authors
 Kyung Young Chung  ;  Se Hoon Kim  ;  Il Hoon Kwon  ;  Young Sik Choi  ;  Tae Woong Noh  ;  Tae Jung Kwon  ;  Dong Hwan Shin 
Citation
 YONSEI MEDICAL JOURNAL, Vol.43(2) : 152-159, 2002 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2002
MeSH
Adult ; Fatal Outcome ; Female ; Humans ; Injections ; Middle Aged ; Pulmonary Embolism/chemically induced* ; Pulmonary Embolism/pathology* ; Silicones/administration & dosage ; Silicones/adverse effects* ; Vagina
Keywords
Silicone ; pulmonary embolism ; retrospective study ; pathology
Abstract
It is known that the subcutaneous injection of silicone can lead to severe pulmonary complications, followed in some patients by respiratory failure. Currently, silicone is being increasingly applied in the field of plastic surgery and, unfortunately, the illicit injection of silicone fluid by uncertified practitioners is not uncommon in Korea. We offer a critical pathologic review of 5 cases of pulmonary silicone embolism following illegal injection to the vaginal wall, four of which were fatal and came to legal autopsy. Our findings again confirm that subcutaneously injected silicone can gain access to the pulmonary vascular tree and cause pulmonary embolism. The histologic changes observed in the lung are variable and include four patterns i.e., the mere presence of silicone emboli, congestion and hemorrhage, acute pneumonitis, and diffuse alveolar damage despite the severe critical course in all cases. We were unable to find any histologic pattern that correlates well with the clinical course. Apart from producing emboli in the pulmonary vessels, subcutaneous injection of silicone can obviously cause serious pulmonary disease due to its ability to induce acute to induce acute pneumonitis and even possibly acute respiratory distress syndrome.
Files in This Item:
T200205743.pdf Download
DOI
10.3349/ymj.2002.43.2.152
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143884
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