Cited 25 times in
Does Race Protect an Oriental Population From Developing Lipodystrophy in HIV-infected Individuals on HAART?
DC Field | Value | Language |
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dc.contributor.author | 김준명 | - |
dc.date.accessioned | 2016-05-16T11:08:15Z | - |
dc.date.available | 2016-05-16T11:08:15Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143870 | - |
dc.description.abstract | Objectives: Lipodystrophy, hyperlipidaemia and hyperinsulinaemia are common metabolic complications of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected Caucasians. We questioned whether such complications also occur in other races. Methods: A cross-sectional analysis was performed in an outpatient clinic of a university teaching hospital with 156 Koreans, divided into HIV-infected subjects receiving HAART (n=57, group 1), HAART-naı̈ve subjects (n=42, group 2), and healthy controls (n=57, group 3). Lipodystrophy was assessed by physical examination and questionnaire and body composition by dual-energy X-ray absorptiometry. Fasting triglyceride, total cholesterol, low-density (LDL) and high-density lipoprotein (HDL) cholesterol, free fatty acid (FFA), Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), glucose, insulin, c-peptide, leptin, cortisol, dehydroepiandrosterone (DHEA), CD4, CD8 lymphocyte counts and HIV RNA load were measured. Results: Lipodystrophy was observed in only 3.5% of HAART-treated HIV-infected Koreans. No statistical difference in regional fat accumulation or peripheral fat wasting was observed between groups 1, 2 and 3. No statistical difference in triglyceride, total cholesterol, LDL cholesterol, FFA, ApoA1, ApoB, glucose, insulin, C-peptide, leptin, cortisol, and DHEA were observed between groups 1, 2 and 3. HDL cholesterol was significantly lower in HIV-infected individuals compared to controls. Conclusions: Lipodystrophy, hyperlipidaemia, and insulin resistance are rare metabolic complications of HAART in an oriental HIV-infected group of individuals. These findings warrant further race-specific metabolic complication studies in HIV-infected subjects receiving HAART. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33~38 | - |
dc.relation.isPartOf | JOURNAL OF INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorptiometry, Photon | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antiretroviral Therapy, Highly Active/adverse effects* | - |
dc.subject.MESH | Asian Continental Ancestry Group* | - |
dc.subject.MESH | Body Composition | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV/genetics | - |
dc.subject.MESH | HIV Infections/drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Lipodystrophy/blood | - |
dc.subject.MESH | Lipodystrophy/chemically induced* | - |
dc.subject.MESH | Lipodystrophy/epidemiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | RNA, Viral/analysis | - |
dc.subject.MESH | Surveys and Questionnaires | - |
dc.subject.MESH | Viral Load | - |
dc.title | Does Race Protect an Oriental Population From Developing Lipodystrophy in HIV-infected Individuals on HAART? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | K.H. Chang | - |
dc.contributor.googleauthor | J.M. Kim | - |
dc.contributor.googleauthor | Y.G. Song | - |
dc.contributor.googleauthor | S.K. Hong | - |
dc.contributor.googleauthor | H.C. Lee | - |
dc.contributor.googleauthor | S.K. Lim | - |
dc.identifier.doi | 10.1053/jinf.2001.0924 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00953 | - |
dc.relation.journalcode | J01452 | - |
dc.identifier.eissn | 1532-2742 | - |
dc.identifier.pmid | 11972416 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0163445301909247?np=y | - |
dc.contributor.alternativeName | Kim, June Myung | - |
dc.contributor.affiliatedAuthor | Kim, June Myung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 38 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTION, Vol.44(1) : 33-38, 2002 | - |
dc.identifier.rimsid | 37624 | - |
dc.type.rims | ART | - |
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