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A phase II study of gemcitiabine monotherapy in breast cancer patients refractory to anthracycline and taxane
DC Field | Value | Language |
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dc.contributor.author | 라선영 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2016-05-16T11:08:02Z | - |
dc.date.available | 2016-05-16T11:08:02Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143862 | - |
dc.description.abstract | Purpose: We performed a phase II trial to evaluate the efficacy and the safety of gemcitabine monotherapy, a pyrimidine antimetabolite, in patients, who had previously failed anthracycline and taxane-based chemotherapy for the treatment of metastatic breast cancer. Materials and Methods: Twenty-one patients with metastatic breast cancer, which was unresponsive to previous chemotherapy, were entered into this study. Gemcitabine was administered at 850 mg/m2, as a 60- minute intravenous infusion on days 1, 8 and 15. This regimen was repeated every 28 days with G-CSF support, but without dose reduction. Results: Objective responses were seen in 6 of the 20 patients who were able to be evaluated (1 complete response and 5 partial responses), with an objective response rate of 30%. The median time to progression was 5 (1∼20) months, and the median overall survival duration was 11 (2∼21) months. The actual dose intensity was 566.7 mg/m2/wk (range; 340∼637.5 mg/m2/wk) and the relative dose intensity was 0.89 (range; 0.40∼1.00). Toxicity was mainly hematological. Toxicities included: grade 3 neutropenia in 20% and anemia in 5%. Grades 3 and 4 thrombocytopenia occurred in 15% of the patients. Conclusion: Gemcitabine monotherapy is an effective and safe treatment for refractory breast cancer patients heavily treated with the anthracycline and taxane- based regimen. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 274~279 | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A phase II study of gemcitiabine monotherapy in breast cancer patients refractory to anthracycline and taxane | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Chul Kim | - |
dc.contributor.googleauthor | Joo Hyuk Sohn | - |
dc.contributor.googleauthor | Yong Tae Kim | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Woo Ick Jang | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.identifier.doi | 10.4143/crt.2002.34.4.274 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 26680875 | - |
dc.subject.keyword | Chemotherapy | - |
dc.subject.keyword | Gemcitabine | - |
dc.subject.keyword | Metastaticbreastneoplasm | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 274 | - |
dc.citation.endPage | 279 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.34(4) : 274-279, 2002 | - |
dc.identifier.rimsid | 37616 | - |
dc.type.rims | ART | - |
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