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휴대용 근적외선 분황분석기를 이용한 비침투 혈당 측정

Other Titles
 Non-invasive Blood Glucose Measurement by a Portable Near Infrared 
 강나루  ;  우영아  ;  차봉수  ;  이현철  ;  김효진 
 약학회지, Vol.46(5) : 331-336, 2002 
Journal Title
Issue Date
NIR ; blood glucose ; non-invasive ; PLSR
The purpose of this study is to develop a non-invasive blood glucose measurement method by a portable near infrared (NIR) system which was newly integrated by our lab. The portable NIR system includes a tungsten halogen lamp, a specialized reflectance fiber optic probe and a photo diode array type InGaAs detector, which was developed by a microchip technology based on the lithography: Reflectance NIR spectra of different parts of human body (finger tip, earlobe, and inner lip) were recorded by using a fiber optic probe. The spectra were collected over the spectral range 1100~1740 nm. Partial least squares regression (PLSR) was applied for the calibration and validation for the determination of blood glucose. The calibration model from earlobe spectra presented better results, showing good correlation with a glucose oxidase method which is a mostly used standard method. This model predicted the glucose concentration for validation set with a SEP of 33 mg/Dl. This study indicated the feasibility for non-invasive monitoring of blood glucose by a portable near ifrared system.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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