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Statistical parametric mapping of LORETA using high density EEG and individual MRI: Application to mismatch negativities in schizophrenia

 Hae Jeong Park  ;  Jun Soo Kwon  ;  Tak Youn  ;  Ji Soo Pae  ;  Jae Jin Kim  ;  Myung Sun Kim  ;  Kyoo Seob Ha 
 HUMAN BRAIN MAPPING, Vol.17(3) : 168-178, 2002 
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Adolescent ; Adult ; Brain Mapping/methods* ; Electroencephalography/methods* ; Electroencephalography/statistics & numerical data* ; Electromagnetic Phenomena ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Magnetic Resonance Imaging/statistics & numerical data* ; Male ; Models, Statistical* ; Schizophrenia/pathology* ; Schizophrenia/physiopathology*
We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the mismatch negativity (MMN) generators in schizophrenia. LORETA, using a realistic head model of the boundary element method derived from the individual anatomy, estimated the current density maps from the scalp topography of the 128-channel EEG. From the current density maps that covered the whole cortical gray matter (up to 20,000 points), volumetric current density images were reconstructed. Intensity normalization of the smoothed current density images was used to reduce the confounding effect of subject specific global activity. After transforming each image into a standard stereotaxic space, we carried out statistical parametric mapping of the normalized current density images. We applied this method to the source localization of MMN in schizophrenia. The MMN generators, produced by a deviant tone of 1,200 Hz (5% of 1,600 trials) under the standard tone of 1,000 Hz, 80 dB binaural stimuli with 300 msec of inter-stimulus interval, were measured in 14 right-handed schizophrenic subjects and 14 age-, gender-, and handedness-matched controls. We found that the schizophrenic group exhibited significant current density reductions of MMN in the left superior temporal gyrus and the left inferior parietal gyrus (P < 0. 0005). This study is the first voxel-by-voxel statistical mapping of current density using individual MRI and high-density EEG. Hum. Brain Mapping 17:168–178, 2002. © 2002 Wiley-Liss, Inc.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
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