Cited 32 times in
Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이문형 | - |
dc.date.accessioned | 2016-05-16T11:05:12Z | - |
dc.date.available | 2016-05-16T11:05:12Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0363-6135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143756 | - |
dc.description.abstract | We hypothesized that partial cellular uncoupling produced by low concentrations of heptanol increases the vulnerability to inducible atrial fibrillation (AF). The epicardial surface of 12 isolated-perfused canine left atria was optically mapped before and after 1–50 μM heptanol infusion. At baseline, no sustained (>30 s) AF could be induced in any of the 12 tissues. However, after 2 μM heptanol infusion, sustained AF was induced in 9 of 12 tissues (P < 0.001). Heptanol >5 μM caused loss of 1:1 capture during rapid pacing, causing no AF to be induced. AF was initiated by conduction block across the fiber leading to reentry, which broke up after one to two rotations into two to four independent wavelets that sustained the AF. Heptanol at 2 μM had no effect on the cellular action potential duration restitution or on the maximal velocity rate over time of the upstroke. The effects of heptanol were reversible. We conclude that partial cellular uncoupling by heptanol without changing atrial active membrane properties promotes wavebreak, reentry, and AF during rapid pacing. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | H1116~H1122 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Action Potentials/drug effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | AtrialFibrillation/chemically induced | - |
dc.subject.MESH | AtrialFibrillation/physiopathology* | - |
dc.subject.MESH | Cell Communication/drug effects* | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Atria/cytology | - |
dc.subject.MESH | Heart Atria/drug effects | - |
dc.subject.MESH | Heart Atria/physiopathology | - |
dc.subject.MESH | Heptanol/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscle Fibers, Skeletal/cytology* | - |
dc.subject.MESH | Muscle Fibers, Skeletal/drug effects | - |
dc.subject.MESH | Myocardium/cytology* | - |
dc.subject.MESH | Pacemaker, Artificial | - |
dc.title | Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Toshihiko Ohara | - |
dc.contributor.googleauthor | Zhilin Qu | - |
dc.contributor.googleauthor | Moon Hyoung Lee | - |
dc.contributor.googleauthor | Keiko Ohara | - |
dc.contributor.googleauthor | Chikaya Omichi | - |
dc.contributor.googleauthor | William J. Mandel | - |
dc.contributor.googleauthor | Peng Sheng Chen | - |
dc.contributor.googleauthor | Hrayr S. Karagueuzian | - |
dc.identifier.doi | 10.1152/ajpheart.00927.2001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02766 | - |
dc.relation.journalcode | J00105 | - |
dc.identifier.eissn | 1522-1539 | - |
dc.identifier.pmid | 12181142 | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 283 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1116 | - |
dc.citation.endPage | 1122 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol.283(3) : 1116-1122, 2002 | - |
dc.identifier.rimsid | 37528 | - |
dc.type.rims | ART | - |
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