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Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2016-05-16T11:04:48Z | - |
dc.date.available | 2016-05-16T11:04:48Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0049-3848 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143741 | - |
dc.description.abstract | von Willebrand factor (vWF) multimeric pattern and von Willebrand factor-cleaving protease activity (vWF-cp) were studied using plasmas from patients with advanced stage- and limited stage-malignant tumors. Deficiency of highly polymeric forms of vWF was observed in plasmas from 7 of 11 patients tested. vWF-cp activity was deficient in plasma samples of six patients with advanced stage-malignant tumors (ranging from 6% to 30% activity of normal plasma), whereas an essentially normal vWF-cp activity was observed in samples taken from patients with limited stage-malignant tumors. Inhibitor of vWF-cp was not detected in any plasma samples tested. To further analyze the relevance of this enzymatic activity in metastatic diagnosis, a study of vWF-cp activity was conducted in 17 patients with colon cancer, and it was shown that deficiency of vWF-cp was associated with the progression of the disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | THROMBOSIS RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ADAM Proteins | - |
dc.subject.MESH | ADAMTS13 Protein | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Colonic Neoplasms/blood | - |
dc.subject.MESH | Colonic Neoplasms/enzymology | - |
dc.subject.MESH | Colonic Neoplasms/pathology | - |
dc.subject.MESH | Dimerization | - |
dc.subject.MESH | DiseaseProgression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metalloendopeptidases/blood | - |
dc.subject.MESH | Metalloendopeptidases/deficiency* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis/diagnosis | - |
dc.subject.MESH | Neoplasms/blood* | - |
dc.subject.MESH | Neoplasms/enzymology | - |
dc.subject.MESH | Neoplasms/pathology | - |
dc.subject.MESH | von WillebrandFactor/metabolism | - |
dc.title | Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Bon Hun Koo | - |
dc.contributor.googleauthor | Doyeun Oh | - |
dc.contributor.googleauthor | So Young Chung | - |
dc.contributor.googleauthor | Nam Keun Kim | - |
dc.contributor.googleauthor | Seonyang Park | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Kwang Hoe Chung | - |
dc.identifier.doi | 1016/S0049-3848(02)00053-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J02727 | - |
dc.identifier.eissn | 1879-2472 | - |
dc.identifier.pmid | 12091044 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0049384802000531# | - |
dc.subject.keyword | von Willebrand factor (vWF) | - |
dc.subject.keyword | von Willebrand factor-cleaving protease (vWF-cp) | - |
dc.subject.keyword | Malignant tumor | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 105 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 471 | - |
dc.citation.endPage | 476 | - |
dc.identifier.bibliographicCitation | THROMBOSIS RESEARCH, Vol.105(6) : 471-476, 2002 | - |
dc.identifier.rimsid | 38636 | - |
dc.type.rims | ART | - |
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