Cited 61 times in
Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer
DC Field | Value | Language |
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dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2016-05-16T11:04:45Z | - |
dc.date.available | 2016-05-16T11:04:45Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0090-4295 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143739 | - |
dc.description.abstract | OBJECTIVES: To determine whether the expression of cyclooxygenase-2 (COX-2) has prognostic significance in Stage T1G3 transitional cell carcinoma of the bladder, the most unfavorable subgroup in terms of recurrence and disease progression. METHODS: Thirty-seven consecutive patients with initial T1G3 transitional cell carcinoma, who had undergone complete transurethral resection, followed by 6 weeks of intravesical instillation of bacille Calmette-Guérin (BCG), and with at least 1 year of follow-up, were enrolled in the study. Paraffin-embedded cancer tissue samples were immunohistochemically stained for COX-2, and possible correlations with clinicopathologic features, such as age, shape and multiplicity of tumor, recurrence, and progression were examined. RESULTS: The median follow-up was 27 months (range 12 to 67). Sixteen patients (43.2%) experienced recurrence and 6 (16.2%) had progression defined as muscle invasion. Of 37 specimens, 16 (43.2%) stained positive for COX-2, defined as 5% or greater of positively stained cancer cells. COX-2 expression was statistically significant in predicting both recurrence (P = 0.0493) and disease progression (P = 0.0272). Patient age and the shape and multiplicity of tumors were not significantly predictive of recurrence or progression. CONCLUSIONS: In a pathologically homogeneous group of T1G3 transitional cell carcinoma of the bladder, the expression of COX-2 correlated with recurrence and progression. Thus, patients with COX-2 positive superficial bladder cancer may need to be followed up more vigorously. Additional studies on the mechanistic implications of COX-2 with respect to recurrence and progression and the possible application of a COX-2 inhibitor to prevent recurrence and progression of superficial bladder cancer are warranted. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 816~821 | - |
dc.relation.isPartOf | UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Transitional Cell/enzymology* | - |
dc.subject.MESH | Carcinoma, Transitional Cell/pathology* | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoenzymes/analysis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Proteins | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | NeoplasmInvasiveness | - |
dc.subject.MESH | NeoplasmProteins/analysis* | - |
dc.subject.MESH | NeoplasmRecurrence, Local/enzymology | - |
dc.subject.MESH | NeoplasmStaging | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prostaglandin-Endoperoxide Synthases/analysis* | - |
dc.subject.MESH | Urinary Bladder Neoplasms/enzymology* | - |
dc.subject.MESH | Urinary Bladder Neoplasms/pathology* | - |
dc.title | Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Sun I.l Kim | - |
dc.contributor.googleauthor | Soo Mee Kwon | - |
dc.contributor.googleauthor | Young Sig Kim | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.identifier.doi | 10.1016/S0090-4295(02)01909-X | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02775 | - |
dc.identifier.eissn | 1527-9995 | - |
dc.identifier.pmid | 12429306 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S009042950201909X?np=y | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 60 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 816 | - |
dc.citation.endPage | 821 | - |
dc.identifier.bibliographicCitation | UROLOGY, Vol.60(5) : 816-821, 2002 | - |
dc.identifier.rimsid | 38634 | - |
dc.type.rims | ART | - |
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