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주의력결핍 과잉행동장애 아동에서 I-123 IPT SPECT로 측정한 기저 신경절 도파민 운반체 밀도

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dc.contributor.author김찬형-
dc.contributor.author남궁기-
dc.contributor.author천근아-
dc.contributor.author유영훈-
dc.contributor.author김영기-
dc.date.accessioned2016-05-16T11:03:41Z-
dc.date.available2016-05-16T11:03:41Z-
dc.date.issued2002-
dc.identifier.issn1017-5717-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143699-
dc.description.abstractObjective: ADHD has been known as a psychiatric disorder in childhood associated with dopamine dysregulation. In the present study, we investigated dopamine transporter (DAT) density using I -123N-(3~iodopropen-2yI)-2β-carbomethoxy-3beta- (4-chlorophenyI) tropane (I -123-IPT)-SPECT in children with ADHD on the hypothesis that alterations of DAT density in the basal ganglia were suggestive of dopaminergic dysfunction in children with ADHD. Methods: Nine drug-naive children with ADHD and six normal children were included in the study. We performed brain SPECT two hours after the intravenous administration of 1-123-IPT and made both quantitative and qualitative analyses using the obtained SPECT data. which were reconstructed for the assessment of specific/nonspecific DAT binding ratios in the basal ganglia. We then investigated the correlation between ADHD Rating Scale (ARS) scores of children with ADHD and specific/nonspecific DAT binding ratios in the basal ganglia. Results: Children with ADHD had significantly greater specific/nonspecific DAT binding ratio of the basal ganglia comparing to normal children. However, no significant correlation were found between ARS scores of children with ADHD and specific/nonspecific DAT binding ratio of basal ganglia in children with ADHD. Conclusion: These finding, support the complex dysregulation of the dopaminergic neurotransmitter system in children with ADHD.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfKorean Journal of Psychopharmacology (대한정신약물학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title주의력결핍 과잉행동장애 아동에서 I-123 IPT SPECT로 측정한 기저 신경절 도파민 운반체 밀도-
dc.title.alternativeDopamine Transporter Density of the Basal Ganglia in Children with Attention Deficit Hyperactivity Disorder Assessed with I-123 IPT SPECT-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthor천근아-
dc.contributor.googleauthor유영훈-
dc.contributor.googleauthor김영기-
dc.contributor.googleauthor남궁기-
dc.contributor.googleauthor김찬형-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01036-
dc.contributor.localIdA01240-
dc.relation.journalcodeJ02107-
dc.contributor.alternativeNameKim, Chan Hyung-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthorKim, Chan Hyung-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.rights.accessRightsfree-
dc.citation.volume13-
dc.citation.number2-
dc.citation.startPage95-
dc.citation.endPage103-
dc.identifier.bibliographicCitationKorean Journal of Psychopharmacology (대한정신약물학회지), Vol.13(2) : 95-103, 2002-
dc.identifier.rimsid38607-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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