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고양이의 가역적 국소 뇌허혈 모델에서 현성확산계수의 회복

Other Titles
 Reversal of apparent diffusion coefficient (ADC) following transient focal cerebral ischemia in cats 
Authors
 김현숙  ;  윤평호  ;  이재환  ;  김동익  ;  이승구  ;  이종두  ;  정은기  ;  이승익  ;  김은주  ;  이병인  ;  윤용규 
Citation
 Journal of the Korean Radiologist Society (대한방사선의학회지), Vol.46(4) : 293-300, 2002 
Journal Title
 Journal of the Korean Radiologist Society (대한방사선의학회지) 
ISSN
 1738-2637 
Issue Date
2002
Keywords
Brain ; infarction
Abstract
Purpose: To determine the minimal threshold ADC ratio suggesting reversible ischemia in a temporary model of MCAO. Materials and Methods: Seven Korean cats weighing 3-3.5 kg were used as a temporary model of MCAO. The MCA was occluded for 1 hour, and diffusion-weighted images (DWI), and ADC and regional cerebral blood volume (rCBV) maps, were obtained at 1, 3, 6 and 24 hours after reperfusion using a 1.5T MR unit. The Cats were sacrificed 24 hours after imaging. Triphenyl tetrazolium chloride (TTC) staining of brain slices was performed, and DWI images and TTC-stained brain slices were compared with the naked eye. Reversible ischemia was defined as the area of high signal intensity at 1-hour DWI that normalized at follow-up DWI and in which TTC staining was normal. Using the ADC image obtained at 1 hour after reperfusion, 60 ADC ratios were obtained in the periphery of the infarct and reversible ischemia. Tissue survival showing normal TTC staining was used for final determination. The sensitivity and specificity of each ADC ratio was obtained and an ROC curve was plotted. Results: Five of seven cats showed the reversible ischemia. An area of high signal intensity was seen on DWI images obtained 1 hour after reperfusion, and this improved at follow-up imaging. The distribution of the ADC ratio in the periphery of the infarct core was 0.71-0.81, and in the periphery of reversible ischemia it was 0.79-0.93. The ADC ratio of 0.80 obtained 1 hr after reperfusion predicted the survival of the ischemic tissue with 93% sensitivity and 90% specificity. The ADC ratio of the reversible ischemia was 0.82±0.03 at 1 hour after reperfusion, and this was higher than that of the infarct, which was 0.74±0.03. Conclusion: The minimal threshold ADC ratio suggesting reversible ischemia in this temporary model of MCAO was 0.80.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Jae Whan(이재환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143545
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