0 102

Cited 0 times in

The role of IL-13 in established allergic airway disease

DC FieldValueLanguage
dc.contributor.author박중원-
dc.date.accessioned2016-05-16T10:59:09Z-
dc.date.available2016-05-16T10:59:09Z-
dc.date.issued2002-
dc.identifier.issn0022-1767-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143536-
dc.description.abstractThe effectiveness of targeting IL-13 in models where airway hyperresponsiveness (AHR) and airway inflammation have already been established is not well-described. We investigated the effects of blocking IL-13 on the early and late phase airway responses and the development of AHR in previously sensitized and challenged mice. BALB/cByJ mice were sensitized (days 1 and 14) and challenged (days 28-30) with OVA. Six weeks later (day 72), previously sensitized/challenged mice were challenged with a single OVA aerosol and the early and late phase response and development of AHR were determined. Specific in vivo blockade of IL-13 was attained after i.p. injection of a soluble IL-13Ralpha2-IgG fusion protein (sIL-13Ralpha2Fc) on days 71-72 for the early and late responses and on days 71-73 for the development of AHR. sIL-13Ralpha2Fc administration inhibited the late, but not early, phase response and the OVA challenge-induced changes in lung resistance and dynamic compliance; as well, sIL-13Ralpha2Fc administration decreased bronchoalveolar lavage eosinophilia and mucus hypersecretion following the secondary challenge protocols. These results demonstrate that targeting IL-13 alone regulates airway responses when administrated to mice with established allergic airway disease. These data identify the importance of IL-13 in the development of allergen-induced altered airway responsiveness following airway challenge, even when administered before rechallenge of mice in which allergic disease had been previously established.-
dc.description.statementOfResponsibilityopen-
dc.format.extent6482~6489-
dc.relation.isPartOfJOURNAL OF IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe role of IL-13 in established allergic airway disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChristian Taube-
dc.contributor.googleauthorCatherine Duez-
dc.contributor.googleauthorZhi-Hua Cui-
dc.contributor.googleauthorKatsuyuki Takeda-
dc.contributor.googleauthorYeong-Ho Rha-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorAnnette Balhorn-
dc.contributor.googleauthorDebra D. Donaldson-
dc.contributor.googleauthorAzzeddine Dakhama-
dc.contributor.googleauthorErwin W. Gelfand-
dc.identifier.doi10.4049/​jimmunol.169.11.6482-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01681-
dc.relation.journalcodeJ01450-
dc.identifier.eissn1550-6606-
dc.identifier.urlhttp://www.jimmunol.org/content/169/11/6482.long-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.rights.accessRightsnot free-
dc.citation.volume169-
dc.citation.number11-
dc.citation.startPage6482-
dc.citation.endPage6489-
dc.identifier.bibliographicCitationJOURNAL OF IMMUNOLOGY, Vol.169(11) : 6482-6489, 2002-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.