Cited 162 times in
The role of IL-13 in established allergic airway disease
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.date.accessioned | 2016-05-16T10:59:09Z | - |
dc.date.available | 2016-05-16T10:59:09Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143536 | - |
dc.description.abstract | The effectiveness of targeting IL-13 in models where airway hyperresponsiveness (AHR) and airway inflammation have already been established is not well-described. We investigated the effects of blocking IL-13 on the early and late phase airway responses and the development of AHR in previously sensitized and challenged mice. BALB/cByJ mice were sensitized (days 1 and 14) and challenged (days 28-30) with OVA. Six weeks later (day 72), previously sensitized/challenged mice were challenged with a single OVA aerosol and the early and late phase response and development of AHR were determined. Specific in vivo blockade of IL-13 was attained after i.p. injection of a soluble IL-13Ralpha2-IgG fusion protein (sIL-13Ralpha2Fc) on days 71-72 for the early and late responses and on days 71-73 for the development of AHR. sIL-13Ralpha2Fc administration inhibited the late, but not early, phase response and the OVA challenge-induced changes in lung resistance and dynamic compliance; as well, sIL-13Ralpha2Fc administration decreased bronchoalveolar lavage eosinophilia and mucus hypersecretion following the secondary challenge protocols. These results demonstrate that targeting IL-13 alone regulates airway responses when administrated to mice with established allergic airway disease. These data identify the importance of IL-13 in the development of allergen-induced altered airway responsiveness following airway challenge, even when administered before rechallenge of mice in which allergic disease had been previously established. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 6482~6489 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The role of IL-13 in established allergic airway disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Christian Taube | - |
dc.contributor.googleauthor | Catherine Duez | - |
dc.contributor.googleauthor | Zhi-Hua Cui | - |
dc.contributor.googleauthor | Katsuyuki Takeda | - |
dc.contributor.googleauthor | Yeong-Ho Rha | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Annette Balhorn | - |
dc.contributor.googleauthor | Debra D. Donaldson | - |
dc.contributor.googleauthor | Azzeddine Dakhama | - |
dc.contributor.googleauthor | Erwin W. Gelfand | - |
dc.identifier.doi | 10.4049/jimmunol.169.11.6482 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01681 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.url | http://www.jimmunol.org/content/169/11/6482.long | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | Park, Jung Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 169 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6482 | - |
dc.citation.endPage | 6489 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.169(11) : 6482-6489, 2002 | - |
dc.identifier.rimsid | 38236 | - |
dc.type.rims | ART | - |
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