Cited 33 times in
Thalidomide Suppresses the Interleukin 1β-Induced NFκB Signaling Pathway in Colon Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 진수현 | - |
dc.contributor.author | 신성관 | - |
dc.contributor.author | 김태일 | - |
dc.date.accessioned | 2016-05-16T10:58:29Z | - |
dc.date.available | 2016-05-16T10:58:29Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143514 | - |
dc.description.abstract | Thalidomide has been shown to have both antiinflammatory and antiangiogenic effects in several diseases. However, its cellular target and mechanism of action are poorly understood. We investigated the action mechanism of thalidomide through the NFκB pathway. Thalidomide inhibited interleukin (IL) 1β-induced NFκB transcriptional activation and IL-8 production in Caco-2 colon cancer cells. In addition, thalidomide suppressed NFκB nuclear translocation, IκB degradation, and NFκB-inducing kinase (NIK)-induced NFκB transcriptional activation. These results suggest that the molecular target of the effects of thalidomide may be IκB phosphorylation by IκB kinase (IKK), whose activation follows NIK activation and precedes IκB degradation in the NFκB pathway. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 414~418 | - |
dc.relation.isPartOf | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Colonic Neoplasms | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-1/antagonists & inhibitors | - |
dc.subject.MESH | Interleukin-1/pharmacology* | - |
dc.subject.MESH | Interleukin-8/biosynthesis | - |
dc.subject.MESH | NF-kappa B/drug effects | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Signal Transduction/drug effects* | - |
dc.subject.MESH | Thalidomide/pharmacology* | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Thalidomide Suppresses the Interleukin 1β-Induced NFκB Signaling Pathway in Colon Cancer Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Soo Hyun Jin | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Dong Soo Han | - |
dc.contributor.googleauthor | Sung Kwan Shin | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.identifier.doi | 10.1111/j.1749-6632.2002.tb04674.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.relation.journalcode | J00181 | - |
dc.identifier.eissn | 1749-6632 | - |
dc.identifier.pmid | 12485902 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2002.tb04674.x/abstract | - |
dc.subject.keyword | thalidomide | - |
dc.subject.keyword | nuclear factor κB (NFκB) | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Jin, Soo Hyun | - |
dc.contributor.alternativeName | Shin, Sung Kwan | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 973 | - |
dc.citation.startPage | 414 | - |
dc.citation.endPage | 418 | - |
dc.identifier.bibliographicCitation | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.973 : 414-418, 2002 | - |
dc.identifier.rimsid | 38218 | - |
dc.type.rims | ART | - |
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