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신생마우스에서 고농도 산소 노출 및 Ascorbate 처치에 따른 폐 조직과 폐내 Interleukin-6의 변화
DC Field | Value | Language |
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dc.contributor.author | 남궁란 | - |
dc.contributor.author | 박국인 | - |
dc.contributor.author | 박민수 | - |
dc.contributor.author | 이철 | - |
dc.date.accessioned | 2016-02-19T11:28:57Z | - |
dc.date.available | 2016-02-19T11:28:57Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1226-1513 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143237 | - |
dc.description.abstract | Purpose: Levels of proinflammatory cytokines such as IL-1, IL-6 and TNF-α have been shown to be increased in the lung of adult mice after exposure to hyperoxia. Ascorbate, a non-enzymatic antioxidant, might have a protective effect against oxygen-induced lung injury. We examined effects of hyperoxia and ascorbate treatment on pulmonary IL-6 levels and pathology in the lungs of newborn mice. Methods: Neonatal mice were exposed to hyperoxia (95% O2) or room air (control) for 24 h or 48 h. Other groups, exposed to hyperoxia for up to 48 h, were injected intraperitoneally preventive doses (0.1 ㎎/10 g mouse weight) or therapeutic doses (1 ㎎/10 g mouse weight) of ascorbate or distilled water (placebo control) twice, immediately before and at 24 h of exposure to hyperoxia. IL-6 concentrations in the supernatant of minced lungs were measured by ELISA. Results: There were no pathologic changes in the lungs except mild emphysema and alveolar hemorrhage. The median pulmonary IL-6 concentration was significantly higher in mice exposed to hyperoxia for 24 h (P<0.05) and for 48 h (P<0.001) than room air controls. There was no difference in pulmonary IL-6 concentration between hyperoxia-exposed (48 h) mice treated with either preventive or therapeutic doses of ascorbate and placebo controls. Conclusion: Neonatal mice exposed to hyperoxia for 24 h and 48 h showed higher pulmonary IL-6 concentrations than room air controls. Preventive or therapeutic doses of ascorbate had no effect on pulmonary IL-6 concentrations nor pulmonary pathology of neonatal mice exposed to hyperoxia for 48 h. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 103~109 | - |
dc.language | Journal of the Korean Society of Neonatology | - |
dc.publisher | Journal of the Korean Society of Neonatology | - |
dc.relation.isPartOf | Journal of the Korean Society of Neonatology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 신생마우스에서 고농도 산소 노출 및 Ascorbate 처치에 따른 폐 조직과 폐내 Interleukin-6의 변화 | - |
dc.title.alternative | Changes in Pulmonary Interleukin-6 and Pulmonary Pathology in Neonatal Mice After Exposure to Hyperoxia and Ascorbate Treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 장혜영 | - |
dc.contributor.googleauthor | 박은혜 | - |
dc.contributor.googleauthor | 오창희 | - |
dc.contributor.googleauthor | 박민수 | - |
dc.contributor.googleauthor | 남궁란 | - |
dc.contributor.googleauthor | 박국인 | - |
dc.contributor.googleauthor | 이철 | - |
dc.contributor.googleauthor | 한동관 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01241 | - |
dc.contributor.localId | A01438 | - |
dc.contributor.localId | A01468 | - |
dc.contributor.localId | A03253 | - |
dc.relation.journalcode | J01883 | - |
dc.identifier.eissn | 2093-7849 | - |
dc.subject.keyword | Hyperoxia | - |
dc.subject.keyword | Interleukin-6 | - |
dc.subject.keyword | Ascorbate | - |
dc.contributor.alternativeName | Namgung, Ran | - |
dc.contributor.alternativeName | Park, Kook In | - |
dc.contributor.alternativeName | Park, Min Soo | - |
dc.contributor.alternativeName | Lee, Chul | - |
dc.contributor.affiliatedAuthor | Namgung, Ran | - |
dc.contributor.affiliatedAuthor | Park, Kook In | - |
dc.contributor.affiliatedAuthor | Park, Min Soo | - |
dc.contributor.affiliatedAuthor | Lee, Chul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 109 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Neonatology, Vol.8(1) : 103-109, 2001 | - |
dc.identifier.rimsid | 39160 | - |
dc.type.rims | ART | - |
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