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신생마우스에서 고농도 산소 노출 및 Ascorbate 처치에 따른 폐 조직과 폐내 Interleukin-6의 변화

DC Field Value Language
dc.contributor.author남궁란-
dc.contributor.author박국인-
dc.contributor.author박민수-
dc.contributor.author이철-
dc.date.accessioned2016-02-19T11:28:57Z-
dc.date.available2016-02-19T11:28:57Z-
dc.date.issued2001-
dc.identifier.issn1226-1513-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143237-
dc.description.abstractPurpose: Levels of proinflammatory cytokines such as IL-1, IL-6 and TNF-α have been shown to be increased in the lung of adult mice after exposure to hyperoxia. Ascorbate, a non-enzymatic antioxidant, might have a protective effect against oxygen-induced lung injury. We examined effects of hyperoxia and ascorbate treatment on pulmonary IL-6 levels and pathology in the lungs of newborn mice. Methods: Neonatal mice were exposed to hyperoxia (95% O2) or room air (control) for 24 h or 48 h. Other groups, exposed to hyperoxia for up to 48 h, were injected intraperitoneally preventive doses (0.1 ㎎/10 g mouse weight) or therapeutic doses (1 ㎎/10 g mouse weight) of ascorbate or distilled water (placebo control) twice, immediately before and at 24 h of exposure to hyperoxia. IL-6 concentrations in the supernatant of minced lungs were measured by ELISA. Results: There were no pathologic changes in the lungs except mild emphysema and alveolar hemorrhage. The median pulmonary IL-6 concentration was significantly higher in mice exposed to hyperoxia for 24 h (P<0.05) and for 48 h (P<0.001) than room air controls. There was no difference in pulmonary IL-6 concentration between hyperoxia-exposed (48 h) mice treated with either preventive or therapeutic doses of ascorbate and placebo controls. Conclusion: Neonatal mice exposed to hyperoxia for 24 h and 48 h showed higher pulmonary IL-6 concentrations than room air controls. Preventive or therapeutic doses of ascorbate had no effect on pulmonary IL-6 concentrations nor pulmonary pathology of neonatal mice exposed to hyperoxia for 48 h.-
dc.description.statementOfResponsibilityopen-
dc.format.extent103~109-
dc.languageJournal of the Korean Society of Neonatology-
dc.publisherJournal of the Korean Society of Neonatology-
dc.relation.isPartOfJournal of the Korean Society of Neonatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title신생마우스에서 고농도 산소 노출 및 Ascorbate 처치에 따른 폐 조직과 폐내 Interleukin-6의 변화-
dc.title.alternativeChanges in Pulmonary Interleukin-6 and Pulmonary Pathology in Neonatal Mice After Exposure to Hyperoxia and Ascorbate Treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthor장혜영-
dc.contributor.googleauthor박은혜-
dc.contributor.googleauthor오창희-
dc.contributor.googleauthor박민수-
dc.contributor.googleauthor남궁란-
dc.contributor.googleauthor박국인-
dc.contributor.googleauthor이철-
dc.contributor.googleauthor한동관-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01241-
dc.contributor.localIdA01438-
dc.contributor.localIdA01468-
dc.contributor.localIdA03253-
dc.relation.journalcodeJ01883-
dc.identifier.eissn2093-7849-
dc.subject.keywordHyperoxia-
dc.subject.keywordInterleukin-6-
dc.subject.keywordAscorbate-
dc.contributor.alternativeNameNamgung, Ran-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNamePark, Min Soo-
dc.contributor.alternativeNameLee, Chul-
dc.contributor.affiliatedAuthorNamgung, Ran-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorPark, Min Soo-
dc.contributor.affiliatedAuthorLee, Chul-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage103-
dc.citation.endPage109-
dc.identifier.bibliographicCitationJournal of the Korean Society of Neonatology, Vol.8(1) : 103-109, 2001-
dc.identifier.rimsid39160-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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